TY - JOUR
T1 - Endothelial and platelet function in children with previous Kawasaki disease
AU - Laurito, Marianna
AU - Stazi, Alessandra
AU - Delogu, Angelica Bibiana
AU - Milo, Maria
AU - Battipaglia, Irma
AU - Scalone, Giancarla
AU - Infusino, Fabio
AU - Villano, Angelo
AU - Russo, Giulio
AU - Iannotta, Rossella
AU - Saracino, Annalisa
AU - Parrinello, Rossella
AU - Figliozzi, Stefano
AU - Sestito, Alfonso
AU - Romagnoli, Costantino
AU - Lanza, Gaetano Antonio
AU - Crea, Filippo
PY - 2014
Y1 - 2014
N2 - We investigated whether children with a previous Kawasaki disease (KD) have evidence of abnormal vascular and/or platelet function. We included 14 patients with previous KD and 14 matched controls. We assessed endothelial function by flow-mediated dilation (FMD), carotid intima-media thickness (cIMT), coronary microvascular function by coronary blood flow response (CBFR) to cold pressor test, and platelet reactivity by measuring monocyte-platelet aggregates (MPAs) and CD41-platelet expression by flow cytometry. No differences were found between the groups in FMD, cIMT, or CBFR to cold pressor test. The MPAs were similar in patients with KD and controls. CD41-platelet expression, however, was significantly increased in patients with KD compared with controls, both at rest (14.3 ± 1.9 vs 12.4 ± 1.9 mean fluorescence intensity [mfi], P = .01) and after adenosine diphosphate stimulation (19.3 ± 1.3 vs 17 ± 1.7 mfi, P < .001). In conclusion, children with a previous episode of KD showed increased platelet activation, compared with healthy participants despite no apparent vascular abnormality at follow-up.
AB - We investigated whether children with a previous Kawasaki disease (KD) have evidence of abnormal vascular and/or platelet function. We included 14 patients with previous KD and 14 matched controls. We assessed endothelial function by flow-mediated dilation (FMD), carotid intima-media thickness (cIMT), coronary microvascular function by coronary blood flow response (CBFR) to cold pressor test, and platelet reactivity by measuring monocyte-platelet aggregates (MPAs) and CD41-platelet expression by flow cytometry. No differences were found between the groups in FMD, cIMT, or CBFR to cold pressor test. The MPAs were similar in patients with KD and controls. CD41-platelet expression, however, was significantly increased in patients with KD compared with controls, both at rest (14.3 ± 1.9 vs 12.4 ± 1.9 mean fluorescence intensity [mfi], P = .01) and after adenosine diphosphate stimulation (19.3 ± 1.3 vs 17 ± 1.7 mfi, P < .001). In conclusion, children with a previous episode of KD showed increased platelet activation, compared with healthy participants despite no apparent vascular abnormality at follow-up.
KW - Adolescent
KW - Blood Platelets
KW - Carotid Intima-Media Thickness
KW - Child
KW - Child, Preschool
KW - Endothelium, Vascular
KW - Female
KW - Humans
KW - Kawasaki disease
KW - Male
KW - Mucocutaneous Lymph Node Syndrome
KW - Platelet Activation
KW - Platelet Aggregation
KW - Platelet Function Tests
KW - carotid intima-medial thickness
KW - endothelial function
KW - platelet function
KW - Adolescent
KW - Blood Platelets
KW - Carotid Intima-Media Thickness
KW - Child
KW - Child, Preschool
KW - Endothelium, Vascular
KW - Female
KW - Humans
KW - Kawasaki disease
KW - Male
KW - Mucocutaneous Lymph Node Syndrome
KW - Platelet Activation
KW - Platelet Aggregation
KW - Platelet Function Tests
KW - carotid intima-medial thickness
KW - endothelial function
KW - platelet function
UR - http://hdl.handle.net/10807/60972
U2 - 10.1177/0003319713502392
DO - 10.1177/0003319713502392
M3 - Article
SN - 0003-3197
VL - 65
SP - 716
EP - 722
JO - Angiology
JF - Angiology
ER -