TY - JOUR
T1 - Endothelial and Platelet Function in Children With Previous Kawasaki Disease
AU - Delogu, Angelica Bibiana
AU - Sestito, Alfonso
AU - Lanza, Gaetano Antonio
AU - Crea, Filippo
AU - Laurito, Marianna
AU - Stazi, Alessandra
AU - Milo, Maria
AU - Battipaglia, Irma
AU - Scalone, Giancarla
AU - Infusino, Fabio
AU - Villano, Angelo
AU - Russo, Giulio
AU - Romagnoli, Costantino
PY - 2013
Y1 - 2013
N2 - We investigated whether children with a previous Kawasaki disease (KD) have evidence of abnormal vascular and/or platelet function. We included 14 patients with previous KD and 14 matched controls. We assessed endothelial function by flow-mediated dilation (FMD), carotid intima-media thickness (cIMT), coronary microvascular function by coronary blood flow response (CBFR) to cold pressor test, and platelet reactivity by measuring monocyte-platelet aggregates (MPAs) and CD41-platelet expression by flow cytometry. No differences were found between the groups in FMD, cIMT, or CBFR to cold pressor test. The MPAs were similar in patients with KD and controls. CD41-platelet expression, however, was significantly increased in patients with KD compared with controls, both at rest (14.3 ± 1.9 vs 12.4 ± 1.9 mean fluorescence intensity [mfi], P = .01) and after adenosine diphosphate stimulation (19.3 ± 1.3 vs 17 ± 1.7 mfi, P < .001). In conclusion, children with a previous episode of KD showed increased platelet activation, compared with healthy participants despite no apparent vascular abnormality at follow-up.
AB - We investigated whether children with a previous Kawasaki disease (KD) have evidence of abnormal vascular and/or platelet function. We included 14 patients with previous KD and 14 matched controls. We assessed endothelial function by flow-mediated dilation (FMD), carotid intima-media thickness (cIMT), coronary microvascular function by coronary blood flow response (CBFR) to cold pressor test, and platelet reactivity by measuring monocyte-platelet aggregates (MPAs) and CD41-platelet expression by flow cytometry. No differences were found between the groups in FMD, cIMT, or CBFR to cold pressor test. The MPAs were similar in patients with KD and controls. CD41-platelet expression, however, was significantly increased in patients with KD compared with controls, both at rest (14.3 ± 1.9 vs 12.4 ± 1.9 mean fluorescence intensity [mfi], P = .01) and after adenosine diphosphate stimulation (19.3 ± 1.3 vs 17 ± 1.7 mfi, P < .001). In conclusion, children with a previous episode of KD showed increased platelet activation, compared with healthy participants despite no apparent vascular abnormality at follow-up.
KW - Kawasaki disease
KW - carotid intima-medial thickness
KW - endothelial function
KW - platelet function
KW - Kawasaki disease
KW - carotid intima-medial thickness
KW - endothelial function
KW - platelet function
UR - http://hdl.handle.net/10807/52621
U2 - 10.1177/0003319713502392
DO - 10.1177/0003319713502392
M3 - Article
SP - N/A-N/A
JO - Angiology
JF - Angiology
SN - 0003-3197
ER -