Abstract
In recent years, extended scientific works shed light on the important role played by
the endometrium in early pregnancy. This review examines our current knowledge
about the delicate balance between microbial and cellular immune agents at endometrial
level: All of them might affect endometrial receptivity. In contrast to the classical
thinking of human endometrium as a sterile tissue, several recent studies have
drawn attention to a resident population of microorganisms, which reaches only a
30% of concordance with those of the cervical‐vaginal flora. At present, the understanding
of the microbiome in relation to human reproduction is in its infancy and
further studies are needed to clarify the activity of endometrial microbiome and the
possible effects of a “reproductive tract dysbiosis” on fertility. Moreover, in the
human endometrium, there is a complex system works preventing the risk of infection
as well as enabling, when pregnancy occurs, the acceptance of the blastocyst. In
this way, the endometrium plays a central role in the uterine immune surveillance. A
better understanding of the different agents that may affect endometrial receptivity
would improve the diagnosis and treatment of obstetric complications related to defective
implantation and placentation.
Lingua originale | English |
---|---|
pagine (da-a) | 1-8 |
Numero di pagine | 8 |
Rivista | American Journal of Reproductive Immunology |
DOI | |
Stato di pubblicazione | Pubblicato - 2018 |
Keywords
- endometrium, infertility, miscarriage, microbiota
- microbiome, inflammation