Endometrial giant cell carcinoma: new insights from a morphological, immunohistochemical, and molecular analysis of three cases

Damiano Arciuolo, Antonio Travaglino, Antonio Raffone, Angela Santoro, Gianluca Russo, Angelo Minucci, Frediano Inzani, Antonio Mollo, Luigi Pedone Anchora, Francesco Fanfani, Luigi Insabato, Gian Franco Zannoni

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Herein, we present a morphological, immunohistochemical, and molecular analysis of three cases of endometrial giant cell carcinoma (EGCC) with a literature review. Patient age was 55 to 76 years. The tumors were limited to the uterus and showed dyshesive, bizarre giant cells with numerous atypical mitoses. Minor components were low-grade endometrioid, spindled/myxoid (case nos. 1 and 2), serous (case no. 3), and undifferentiated (all cases). The giant cells were e-cadherin-, cytokeratins/EMA + (focal/multifocal), hormone receptors + (focal/multifocal), vimentin + , p16 + (diffuse), CD68-, α-FP-, β-HCG-, muscle markers-, CD10-, and ERG-. Case no. 3 was p53-abnormal. All cases were mismatch repair-proficient and microsatellite-stable. No POLE mutations were detected. Based on our and previous reports, EGCC is often accompanied by a conventional carcinomatous component (mostly endometrioid) and shows partial loss epithelial markers and negativity for specific differentiation markers. EGCC shows evident similarities to both undifferentiated/dedifferentiated carcinoma and carcinosarcoma and should be managed similarly. Unlike the latter two, EGCC might preferentially derive from “no-specific-molecular-profile” carcinomas.
Lingua originaleEnglish
pagine (da-a)1-5
Numero di pagine5
RivistaVirchows Archiv
DOI
Stato di pubblicazionePubblicato - 2022

Keywords

  • Carcinosarcoma
  • Endometrial carcinoma
  • Giant cell carcinoma
  • Mismatch repair
  • p53

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