Endocrine Disruptors in Food, Estrobolome and Breast Cancer

Alessio Filippone, Cristina Rossi, Maria Maddalena Rossi, Annalisa Di Micco, Claudia Maggiore, Luana Forcina, Maria Natale, Lara Costantini, Nicolò Merendino, Alba Di Leone, Gianluca Franceschini, Riccardo Masetti, Stefano Magno

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

The microbiota is now recognized as one of the major players in human health and diseases, including cancer. Regarding breast cancer (BC), a clear link between microbiota and oncogenesis still needs to be confirmed. Yet, part of the bacterial gene mass inside the gut, constituting the so called “estrobolome”, influences sexual hormonal balance and, since the increased exposure to estrogens is associated with an increased risk, may impact on the onset, progression, and treatment of hormonal dependent cancers (which account for more than 70% of all BCs). The hormonal dependent BCs are also affected by environmental and dietary endocrine disruptors and phytoestrogens which interact with microbiota in a bidirectional way: on the one side disruptors can alter the composition and functions of the estrobolome, ad on the other the gut microbiota influences the metabolism of endocrine active food components. This review highlights the current evidence about the complex interplay between endocrine disruptors, phytoestrogens, microbiome, and BC, within the frames of a new “oncobiotic” perspective.
Lingua originaleEnglish
pagine (da-a)1-14
Numero di pagine14
RivistaJournal of Clinical Medicine
Volume12
DOI
Stato di pubblicazionePubblicato - 2023

Keywords

  • endocrine disruptors
  • estrobolome
  • microbiome
  • oncobiotic
  • personalized medicine

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