TY - JOUR
T1 - Endocrine Disruptors in Food, Estrobolome and Breast Cancer
AU - Filippone, Alessio
AU - Rossi, Cristina
AU - Rossi, Maria Maddalena
AU - Di Micco, Annalisa
AU - Maggiore, Claudia
AU - Forcina, Luana
AU - Natale, Maria
AU - Costantini, Lara
AU - Merendino, Nicolò
AU - Di Leone, Alba
AU - Franceschini, Gianluca
AU - Masetti, Riccardo
AU - Magno, Stefano
PY - 2023
Y1 - 2023
N2 - The microbiota is now recognized as one of the major players in human health and diseases, including cancer. Regarding breast cancer (BC), a clear link between microbiota and oncogenesis still needs to be confirmed. Yet, part of the bacterial gene mass inside the gut, constituting the so called “estrobolome”, influences sexual hormonal balance and, since the increased exposure to estrogens is associated with an increased risk, may impact on the onset, progression, and treatment of hormonal dependent cancers (which account for more than 70% of all BCs). The hormonal dependent BCs are also affected by environmental and dietary endocrine disruptors and phytoestrogens which interact with microbiota in a bidirectional way: on the one side disruptors can alter the composition and functions of the estrobolome, ad on the other the gut microbiota influences the metabolism of endocrine active food components. This review highlights the current evidence about the complex interplay between endocrine disruptors, phytoestrogens, microbiome, and BC, within the frames of a new “oncobiotic” perspective.
AB - The microbiota is now recognized as one of the major players in human health and diseases, including cancer. Regarding breast cancer (BC), a clear link between microbiota and oncogenesis still needs to be confirmed. Yet, part of the bacterial gene mass inside the gut, constituting the so called “estrobolome”, influences sexual hormonal balance and, since the increased exposure to estrogens is associated with an increased risk, may impact on the onset, progression, and treatment of hormonal dependent cancers (which account for more than 70% of all BCs). The hormonal dependent BCs are also affected by environmental and dietary endocrine disruptors and phytoestrogens which interact with microbiota in a bidirectional way: on the one side disruptors can alter the composition and functions of the estrobolome, ad on the other the gut microbiota influences the metabolism of endocrine active food components. This review highlights the current evidence about the complex interplay between endocrine disruptors, phytoestrogens, microbiome, and BC, within the frames of a new “oncobiotic” perspective.
KW - endocrine disruptors
KW - estrobolome
KW - microbiome
KW - oncobiotic
KW - personalized medicine
KW - endocrine disruptors
KW - estrobolome
KW - microbiome
KW - oncobiotic
KW - personalized medicine
UR - http://hdl.handle.net/10807/260215
U2 - 10.3390/jcm12093158
DO - 10.3390/jcm12093158
M3 - Article
SN - 2077-0383
VL - 12
SP - 1
EP - 14
JO - Journal of Clinical Medicine
JF - Journal of Clinical Medicine
ER -