Endocrine disruptors and human corpus luteum: in vitro effects of phenols on luteal cells function

Federica Romani; Anna Tropea; Elisa Scarinci; Cinzia Dello Russo; Lucia Lisi; Stefania Catino; Antonio Lanzone; Rosanna Apa

doi:10.1080/10590501.2013.782180

Endocrine disruptors and human corpus luteum: in vitro effects of phenols on luteal cells function

Federica Romani, Anna Tropea, Elisa Scarinci, Cinzia Dello Russo, Lucia Lisi, Stefania Catino, Antonio Lanzone, Rosanna Apa

IRCCS Oasi Maria SS. - Troina (EN)

Risultato della ricerca: Contributo in rivista › Articolo in rivista

10 Citazioni (Scopus)

Abstract

Endocrine disruptors are well known to impair fertility. The aim of the present study was to investigate the effects of bisphenol A (BPA) and nonylphenol (p-NP) on human luteal function in vitro. In particular, in luteal cells isolated from 21 human corpora lutea progesterone, prostaglandin (PG) F2α, PGE2 and vascular endothelial growth factor (VEGF) release, as well as VEGF expression were evaluated. BPA and p-NP negatively affected both luteal steroidogenesis and luteotrophic/ luteolytic factors balance, without influencing VEGF mRNA expression. Actually, BPA and p-NP impaired human luteal cells function in vitro, underlining the already suggested correlation between phenols and reproductive failure.

Lingua originale	English
pagine (da-a)	170-180
Numero di pagine	11
Rivista	JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH. PART C, ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS
Volume	31
DOI	https://doi.org/10.1080/10590501.2013.782180
Stato di pubblicazione	Pubblicato - 2013

Keywords

Adult
Benzhydryl Compounds
Cells, Cultured
Dinoprost
Dinoprostone
Endocrine Disruptors
Environmental Pollutants
Enzyme-Linked Immunosorbent Assay
Female
Humans
Immunoenzyme Techniques
Luteal Cells
Phenols
Progesterone
RNA, Messenger
Real-Time Polymerase Chain Reaction
Vascular Endothelial Growth Factor A

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10.1080/10590501.2013.782180

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Romani, F., Tropea, A., Scarinci, E., Dello Russo, C., Lisi, L., Catino, S., Lanzone, A., & Apa, R. (2013). Endocrine disruptors and human corpus luteum: in vitro effects of phenols on luteal cells function. JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH. PART C, ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS, 31, 170-180. https://doi.org/10.1080/10590501.2013.782180

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abstract = "Endocrine disruptors are well known to impair fertility. The aim of the present study was to investigate the effects of bisphenol A (BPA) and nonylphenol (p-NP) on human luteal function in vitro. In particular, in luteal cells isolated from 21 human corpora lutea progesterone, prostaglandin (PG) F2α, PGE2 and vascular endothelial growth factor (VEGF) release, as well as VEGF expression were evaluated. BPA and p-NP negatively affected both luteal steroidogenesis and luteotrophic/ luteolytic factors balance, without influencing VEGF mRNA expression. Actually, BPA and p-NP impaired human luteal cells function in vitro, underlining the already suggested correlation between phenols and reproductive failure.",

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author = "Federica Romani and Anna Tropea and Elisa Scarinci and {Dello Russo}, Cinzia and Lucia Lisi and Stefania Catino and Antonio Lanzone and Rosanna Apa",

year = "2013",

doi = "10.1080/10590501.2013.782180",

language = "English",

volume = "31",

pages = "170--180",

journal = "JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH. PART C, ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS",

issn = "1059-0501",

publisher = "Marcel Dekker Incorporated:270 Madison Avenue:New York, NY 10016:(800)228-1160, (212)696-9000, EMAIL: [email protected], INTERNET: http://www.dekker.com, Fax: (212)685-4540",

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Romani, F, Tropea, A, Scarinci, E, Dello Russo, C , Lisi, L, Catino, S, Lanzone, A & Apa, R 2013, 'Endocrine disruptors and human corpus luteum: in vitro effects of phenols on luteal cells function', JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH. PART C, ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS, vol. 31, pagg. 170-180. https://doi.org/10.1080/10590501.2013.782180

Endocrine disruptors and human corpus luteum: in vitro effects of phenols on luteal cells function. / Romani, Federica; Tropea, Anna; Scarinci, Elisa et al.
In: JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH. PART C, ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS, Vol. 31, 2013, pag. 170-180.

Risultato della ricerca: Contributo in rivista › Articolo in rivista

TY - JOUR

T1 - Endocrine disruptors and human corpus luteum: in vitro effects of phenols on luteal cells function

AU - Romani, Federica

AU - Tropea, Anna

AU - Scarinci, Elisa

AU - Dello Russo, Cinzia

AU - Lisi, Lucia

AU - Catino, Stefania

AU - Lanzone, Antonio

AU - Apa, Rosanna

PY - 2013

Y1 - 2013

N2 - Endocrine disruptors are well known to impair fertility. The aim of the present study was to investigate the effects of bisphenol A (BPA) and nonylphenol (p-NP) on human luteal function in vitro. In particular, in luteal cells isolated from 21 human corpora lutea progesterone, prostaglandin (PG) F2α, PGE2 and vascular endothelial growth factor (VEGF) release, as well as VEGF expression were evaluated. BPA and p-NP negatively affected both luteal steroidogenesis and luteotrophic/ luteolytic factors balance, without influencing VEGF mRNA expression. Actually, BPA and p-NP impaired human luteal cells function in vitro, underlining the already suggested correlation between phenols and reproductive failure.

AB - Endocrine disruptors are well known to impair fertility. The aim of the present study was to investigate the effects of bisphenol A (BPA) and nonylphenol (p-NP) on human luteal function in vitro. In particular, in luteal cells isolated from 21 human corpora lutea progesterone, prostaglandin (PG) F2α, PGE2 and vascular endothelial growth factor (VEGF) release, as well as VEGF expression were evaluated. BPA and p-NP negatively affected both luteal steroidogenesis and luteotrophic/ luteolytic factors balance, without influencing VEGF mRNA expression. Actually, BPA and p-NP impaired human luteal cells function in vitro, underlining the already suggested correlation between phenols and reproductive failure.

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KW - Benzhydryl Compounds

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KW - Environmental Pollutants

KW - Enzyme-Linked Immunosorbent Assay

KW - Female

KW - Humans

KW - Immunoenzyme Techniques

KW - Luteal Cells

KW - Phenols

KW - Progesterone

KW - RNA, Messenger

KW - Real-Time Polymerase Chain Reaction

KW - Vascular Endothelial Growth Factor A

KW - Adult

KW - Benzhydryl Compounds

KW - Cells, Cultured

KW - Dinoprost

KW - Dinoprostone

KW - Endocrine Disruptors

KW - Environmental Pollutants

KW - Enzyme-Linked Immunosorbent Assay

KW - Female

KW - Humans

KW - Immunoenzyme Techniques

KW - Luteal Cells

KW - Phenols

KW - Progesterone

KW - RNA, Messenger

KW - Real-Time Polymerase Chain Reaction

KW - Vascular Endothelial Growth Factor A

UR - http://hdl.handle.net/10807/53319

U2 - 10.1080/10590501.2013.782180

DO - 10.1080/10590501.2013.782180

M3 - Article

SN - 1059-0501

VL - 31

SP - 170

EP - 180

JO - JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH. PART C, ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS

JF - JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH. PART C, ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS

ER -

Endocrine disruptors and human corpus luteum: in vitro effects of phenols on luteal cells function

Abstract

Keywords

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