Endocrine disruptors and human corpus luteum: in vitro effects of phenols on luteal cells function

Cinzia Dello Russo, Lucia Lisi, Antonio Lanzone, Rosanna Apa, Federica Romani, Anna Tropea, Elisa Scarinci, Stefania Catino

Risultato della ricerca: Contributo in rivistaArticolo in rivista

10 Citazioni (Scopus)

Abstract

Endocrine disruptors are well known to impair fertility. The aim of the present study was to investigate the effects of bisphenol A (BPA) and nonylphenol (p-NP) on human luteal function in vitro. In particular, in luteal cells isolated from 21 human corpora lutea progesterone, prostaglandin (PG) F2α, PGE2 and vascular endothelial growth factor (VEGF) release, as well as VEGF expression were evaluated. BPA and p-NP negatively affected both luteal steroidogenesis and luteotrophic/ luteolytic factors balance, without influencing VEGF mRNA expression. Actually, BPA and p-NP impaired human luteal cells function in vitro, underlining the already suggested correlation between phenols and reproductive failure.
Lingua originaleEnglish
pagine (da-a)170-180
Numero di pagine11
RivistaJOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH. PART C, ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS
Volume31
DOI
Stato di pubblicazionePubblicato - 2013

Keywords

  • Adult
  • Benzhydryl Compounds
  • Cells, Cultured
  • Dinoprost
  • Dinoprostone
  • Endocrine Disruptors
  • Environmental Pollutants
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Immunoenzyme Techniques
  • Luteal Cells
  • Phenols
  • Progesterone
  • RNA, Messenger
  • Real-Time Polymerase Chain Reaction
  • Vascular Endothelial Growth Factor A

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