TY - JOUR
T1 - Endocrine and Metabolic Insights from Pancreatic Surgery
AU - Mezza, Teresa
AU - Cefalo, Chiara Maria Assunta
AU - Cinti, Francesca
AU - Quero, Giuseppe
AU - Pontecorvi, Alfredo
AU - Alfieri, Sergio
AU - Holst, Jens J.
AU - Giaccari, Andrea
PY - 2020
Y1 - 2020
N2 - Although it is well established that diabetes can also develop as a result of diseases or maneuvers on the exocrine pancreas, the complex relationship between glucose disorders and underlying pancreatic disease is still debated. There is evidence that several features linked to pancreatic diseases can modify endocrine and metabolic conditions before and after surgery. However, pancreatic surgery provides a rare opportunity to correlate in vivo endocrine and metabolic pathways with ex vivo pancreatic samples, to examine the endocrine and metabolic effects of acute islet removal, and finally to clarify the pathogenesis of diabetes. This approach could therefore represent a unique method to shed light on the molecular mechanisms, predicting factors, and metabolic consequences of insulin resistance, islet plasticity, β cell failure, and type 2 diabetes.
AB - Although it is well established that diabetes can also develop as a result of diseases or maneuvers on the exocrine pancreas, the complex relationship between glucose disorders and underlying pancreatic disease is still debated. There is evidence that several features linked to pancreatic diseases can modify endocrine and metabolic conditions before and after surgery. However, pancreatic surgery provides a rare opportunity to correlate in vivo endocrine and metabolic pathways with ex vivo pancreatic samples, to examine the endocrine and metabolic effects of acute islet removal, and finally to clarify the pathogenesis of diabetes. This approach could therefore represent a unique method to shed light on the molecular mechanisms, predicting factors, and metabolic consequences of insulin resistance, islet plasticity, β cell failure, and type 2 diabetes.
KW - pancreatic disease
KW - pancreatic surgery
KW - personalized medicine
KW - type 2 diabetes mellitus
KW - pancreatic disease
KW - pancreatic surgery
KW - personalized medicine
KW - type 2 diabetes mellitus
UR - http://hdl.handle.net/10807/162329
U2 - 10.1016/j.tem.2020.07.003
DO - 10.1016/j.tem.2020.07.003
M3 - Article
SN - 1043-2760
VL - 31
SP - 760
EP - 772
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
ER -