TY - JOUR
T1 - Emerging Role of Semaphorins as Major Regulatory Signals and Potential Therapeutic Targets in Cancer
AU - Tamagnone, Luca
PY - 2012
Y1 - 2012
N2 - Semaphorins are mainly known as guidance signals in development, acting through receptors called Plexins. However, their role in cancer is rapidly emerging in the regulation of tumor angiogenesis, tumor growth, cancer cell invasiveness, and metastatic spreading. Intriguingly, activated plexins can transactivate receptor tyrosine kinases, such as MET, VEGFR2, FGFR2, and ERBB2, and lead to distinctive effects in a cell-context-dependent manner. Moreover, certain semaphorins concomitantly target endothelial and cancer cells, and can achieve remarkable inhibition of angiogenesis and tumor growth, associated with anti-metastatic activity. Altogether, these data validate the identification of semaphorin signals as promising therapeutic targets in cancer. © 2012 Elsevier Inc.
AB - Semaphorins are mainly known as guidance signals in development, acting through receptors called Plexins. However, their role in cancer is rapidly emerging in the regulation of tumor angiogenesis, tumor growth, cancer cell invasiveness, and metastatic spreading. Intriguingly, activated plexins can transactivate receptor tyrosine kinases, such as MET, VEGFR2, FGFR2, and ERBB2, and lead to distinctive effects in a cell-context-dependent manner. Moreover, certain semaphorins concomitantly target endothelial and cancer cells, and can achieve remarkable inhibition of angiogenesis and tumor growth, associated with anti-metastatic activity. Altogether, these data validate the identification of semaphorin signals as promising therapeutic targets in cancer. © 2012 Elsevier Inc.
KW - ERBB2
KW - FGFR2
KW - MET
KW - PLEXINS
KW - SEMAPHORINS
KW - VEGFR2
KW - ERBB2
KW - FGFR2
KW - MET
KW - PLEXINS
KW - SEMAPHORINS
KW - VEGFR2
UR - https://publicatt.unicatt.it/handle/10807/140950
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84865137629&origin=inward
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84865137629&origin=inward
U2 - 10.1016/j.ccr.2012.06.031
DO - 10.1016/j.ccr.2012.06.031
M3 - Article
SN - 1535-6108
VL - 22
SP - 145
EP - 152
JO - Cancer Cell
JF - Cancer Cell
IS - 2
ER -