Emerging Direct Targeting β-Catenin Agents

Marianna Nalli; Domiziana Masci; Andrea Urbani; Giuseppe La Regina; Romano Silvestri

doi:10.3390/molecules27227735

Emerging Direct Targeting β-Catenin Agents

Marianna Nalli
, Domiziana Masci
, Andrea Urbani
, Giuseppe La Regina
, Romano Silvestri^*

^*Autore corrispondente per questo lavoro

Dipartimento di Scienze biotecnologiche di base, cliniche intensivologiche e perioperatorie
Facoltà di Medicina e Chirurgia "A.Gemelli"
Ambito Disciplinare: CHIMICA FARMACEUTICA, TOSSICOLOGICA, NUTRACEUTICO-ALIMENTARE, DELLE FERMENTAZIONI E DEI PRODOTTI PER IL BENESSERE E PER LA SALUTE
Ambito Disciplinare: BIOCHIMICA CLINICA E BIOLOGIA MOLECOLARE CLINICA

University of Rome La Sapienza

Risultato della ricerca: Contributo in rivista › Articolo

Abstract

Aberrant accumulation of beta-catenin in the cell nucleus as a result of deregulation of the Wnt/beta-catenin pathway is found in various types of cancer. Direct beta-catenin targeting agents are being researched despite obstacles; however, specific beta-catenin drugs for clinical treatments have not been approved so far. We focused on direct beta-catenin targeting of potential therapeutic value as anticancer agents. This review provides recent advances on small molecule beta-catenin agents. Structure-activity relationships and biological activities of reported inhibitors are discussed. This work provides useful knowledge in the discovery of beta-catenin agents.

Lingua originale	Inglese
pagine (da-a)	1-15
Numero di pagine	15
Rivista	Molecules
Volume	27
Numero di pubblicazione	22
DOI	https://doi.org/10.3390/molecules27227735
Stato di pubblicazione	Pubblicato - 2022

OSS delle Nazioni Unite

Questo processo contribuisce al raggiungimento dei seguenti obiettivi di sviluppo sostenibile

SDG 3 Salute e benessere

All Science Journal Classification (ASJC) codes

Chimica Analitica
Chimica (varie)
Medicina Molecolare
Scienze Farmaceutiche
Nuovi Farmaci
Chimica Fisica e Teorica
Chimica Organica

Keywords

anticancer agent
inhibitor
small molecule
β-catenin

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10.3390/molecules27227735

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title = "Emerging Direct Targeting β-Catenin Agents",

abstract = "Aberrant accumulation of beta-catenin in the cell nucleus as a result of deregulation of the Wnt/beta-catenin pathway is found in various types of cancer. Direct beta-catenin targeting agents are being researched despite obstacles; however, specific beta-catenin drugs for clinical treatments have not been approved so far. We focused on direct beta-catenin targeting of potential therapeutic value as anticancer agents. This review provides recent advances on small molecule beta-catenin agents. Structure-activity relationships and biological activities of reported inhibitors are discussed. This work provides useful knowledge in the discovery of beta-catenin agents.",

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year = "2022",

doi = "10.3390/molecules27227735",

language = "English",

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AU - Masci, Domiziana

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AU - La Regina, Giuseppe

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PY - 2022

Y1 - 2022

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AB - Aberrant accumulation of beta-catenin in the cell nucleus as a result of deregulation of the Wnt/beta-catenin pathway is found in various types of cancer. Direct beta-catenin targeting agents are being researched despite obstacles; however, specific beta-catenin drugs for clinical treatments have not been approved so far. We focused on direct beta-catenin targeting of potential therapeutic value as anticancer agents. This review provides recent advances on small molecule beta-catenin agents. Structure-activity relationships and biological activities of reported inhibitors are discussed. This work provides useful knowledge in the discovery of beta-catenin agents.

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Emerging Direct Targeting β-Catenin Agents

Abstract

OSS delle Nazioni Unite

All Science Journal Classification (ASJC) codes

Keywords

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