Emerging Direct Targeting β-Catenin Agents

Marianna Nalli; Domiziana Masci; Andrea Urbani; Giuseppe La Regina; Romano Silvestri

doi:10.3390/molecules27227735

Emerging Direct Targeting β-Catenin Agents

Marianna Nalli, Domiziana Masci, Andrea Urbani, Giuseppe La Regina, Romano Silvestri^*

^*Autore corrispondente per questo lavoro

University of Rome La Sapienza

Risultato della ricerca: Contributo in rivista › Articolo in rivista

Abstract

Aberrant accumulation of beta-catenin in the cell nucleus as a result of deregulation of the Wnt/beta-catenin pathway is found in various types of cancer. Direct beta-catenin targeting agents are being researched despite obstacles; however, specific beta-catenin drugs for clinical treatments have not been approved so far. We focused on direct beta-catenin targeting of potential therapeutic value as anticancer agents. This review provides recent advances on small molecule beta-catenin agents. Structure-activity relationships and biological activities of reported inhibitors are discussed. This work provides useful knowledge in the discovery of beta-catenin agents.

Lingua originale	English
pagine (da-a)	1-15
Numero di pagine	15
Rivista	Molecules
Volume	27
DOI	https://doi.org/10.3390/molecules27227735
Stato di pubblicazione	Pubblicato - 2022

Keywords

anticancer agent
inhibitor
small molecule
β-catenin

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title = "Emerging Direct Targeting β-Catenin Agents",

abstract = "Aberrant accumulation of beta-catenin in the cell nucleus as a result of deregulation of the Wnt/beta-catenin pathway is found in various types of cancer. Direct beta-catenin targeting agents are being researched despite obstacles; however, specific beta-catenin drugs for clinical treatments have not been approved so far. We focused on direct beta-catenin targeting of potential therapeutic value as anticancer agents. This review provides recent advances on small molecule beta-catenin agents. Structure-activity relationships and biological activities of reported inhibitors are discussed. This work provides useful knowledge in the discovery of beta-catenin agents.",

keywords = "anticancer agent, inhibitor, small molecule, β-catenin, anticancer agent, inhibitor, small molecule, β-catenin",

author = "Marianna Nalli and Domiziana Masci and Andrea Urbani and {La Regina}, Giuseppe and Romano Silvestri",

year = "2022",

doi = "10.3390/molecules27227735",

language = "English",

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journal = "Molecules",

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T1 - Emerging Direct Targeting β-Catenin Agents

AU - Nalli, Marianna

AU - Masci, Domiziana

AU - Urbani, Andrea

AU - La Regina, Giuseppe

AU - Silvestri, Romano

PY - 2022

Y1 - 2022

N2 - Aberrant accumulation of beta-catenin in the cell nucleus as a result of deregulation of the Wnt/beta-catenin pathway is found in various types of cancer. Direct beta-catenin targeting agents are being researched despite obstacles; however, specific beta-catenin drugs for clinical treatments have not been approved so far. We focused on direct beta-catenin targeting of potential therapeutic value as anticancer agents. This review provides recent advances on small molecule beta-catenin agents. Structure-activity relationships and biological activities of reported inhibitors are discussed. This work provides useful knowledge in the discovery of beta-catenin agents.

AB - Aberrant accumulation of beta-catenin in the cell nucleus as a result of deregulation of the Wnt/beta-catenin pathway is found in various types of cancer. Direct beta-catenin targeting agents are being researched despite obstacles; however, specific beta-catenin drugs for clinical treatments have not been approved so far. We focused on direct beta-catenin targeting of potential therapeutic value as anticancer agents. This review provides recent advances on small molecule beta-catenin agents. Structure-activity relationships and biological activities of reported inhibitors are discussed. This work provides useful knowledge in the discovery of beta-catenin agents.

KW - anticancer agent

KW - inhibitor

KW - small molecule

KW - β-catenin

KW - anticancer agent

KW - inhibitor

KW - small molecule

KW - β-catenin

UR - http://hdl.handle.net/10807/268797

U2 - 10.3390/molecules27227735

DO - 10.3390/molecules27227735

M3 - Article

SN - 1420-3049

VL - 27

SP - 1

EP - 15

JO - Molecules

JF - Molecules

ER -

Emerging Direct Targeting β-Catenin Agents

Abstract

Keywords

OSS delle Nazioni Unite

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