TY - JOUR
T1 - Elimination of Mother-To-Child Transmission of HIV Infection: The Drug Resource Enhancement against AIDS and Malnutrition Model
AU - De Luca, Andrea
AU - Liotta, Giuseppe
AU - Marazzi, Maria Cristina
AU - Mothibi, Khethimipilo E.
AU - Zimba, Ines
AU - Amangoua, Evelyne E.
AU - Bonje, Esther K.
AU - Bossiky, Bernard N. B.
AU - Robinson, Precious A.
AU - Scarcella, Paola
AU - Musokotwane, Kebby
AU - Palombi, Leonardo
AU - Germano, Paola
AU - Narciso, Pasquale
AU - Alumando, Elard
AU - Mamary, Sangare H.
AU - Magid, Nurja A.
AU - Guidotti, Giovanni
AU - Mancinelli, Sandro
AU - Orlando, Stefano
AU - Peroni, Marco
AU - Buonomo, Ersilia
AU - Nielsen-Saines, Karin
PY - 2015
Y1 - 2015
N2 - The Drug Resource Enhancement against AIDS and Malnutrition Program (DREAM) gathered professionals in the field of Elimination of HIV-Mother-To-Child Transmission (EMTCT) in Maputo in 2013 to discuss obstacles and solutions for the elimination of HIV vertical transmission in sub-Saharan Africa. During this workshop, the benefits of administrating combined antiretroviral therapy (cART) to HIV positive women from pregnancy throughout breastfeeding were reviewed. cART is capable of reducing vertical transmission to less than 5% at 24 months of age, as well as maternal mortality and infant mortality in both HIV infected and exposed populations to levels similar to those of uninfected individuals. The challenge for programs targeting eMTCT in developing countries is retention in care and treatment adherence. Both are intrinsically related to the model of care. The drop-out from eMTCT programs before cART initiation ranges from 33%-88% while retention rates at 18-24 months are less than 50%. Comprehensive strategies including peer-to-peer education, social support and laboratory monitoring can reduce refusals to less than 5% and attain retention rates approaching 90%. Several components of the model of care for reduction of HIV-1 MTCT are feasible and implementable in scale-up strategies. A review of this model of care for HIV eMTCT is provided.
AB - The Drug Resource Enhancement against AIDS and Malnutrition Program (DREAM) gathered professionals in the field of Elimination of HIV-Mother-To-Child Transmission (EMTCT) in Maputo in 2013 to discuss obstacles and solutions for the elimination of HIV vertical transmission in sub-Saharan Africa. During this workshop, the benefits of administrating combined antiretroviral therapy (cART) to HIV positive women from pregnancy throughout breastfeeding were reviewed. cART is capable of reducing vertical transmission to less than 5% at 24 months of age, as well as maternal mortality and infant mortality in both HIV infected and exposed populations to levels similar to those of uninfected individuals. The challenge for programs targeting eMTCT in developing countries is retention in care and treatment adherence. Both are intrinsically related to the model of care. The drop-out from eMTCT programs before cART initiation ranges from 33%-88% while retention rates at 18-24 months are less than 50%. Comprehensive strategies including peer-to-peer education, social support and laboratory monitoring can reduce refusals to less than 5% and attain retention rates approaching 90%. Several components of the model of care for reduction of HIV-1 MTCT are feasible and implementable in scale-up strategies. A review of this model of care for HIV eMTCT is provided.
KW - DREAM program
KW - elimination of HIV MTCT
KW - DREAM program
KW - elimination of HIV MTCT
UR - http://hdl.handle.net/10807/68435
U2 - 10.3390/ijerph121013224
DO - 10.3390/ijerph121013224
M3 - Article
VL - 12
SP - 13224
EP - 13239
JO - International Journal of Environmental Research and Public Health
JF - International Journal of Environmental Research and Public Health
SN - 1661-7827
ER -