Elevated admission cardiac troponin T is associated with microvascular dysfunction in acute myocardial infarction treated with emergency angioplasty

Francesco Burzotta, Carlo Trani, Antonella Lombardo, Luigi Natale, Luigi Marzio Biasucci, Filippo Crea, Italo Porto, Elisa Romagnoli, Giampaolo Niccoli, Antonio Maria Leone

Risultato della ricerca: Contributo in rivistaArticolo in rivista

4 Citazioni (Scopus)

Abstract

BACKGROUND: We speculated that elevated admission cardiac troponin T (cTnT) could predict worse microvascular function in patients with ST-elevation myocardial infarction who are managed with emergency percutaneous coronary intervention. METHODS: In 27 patients with ST-elevation myocardial infarction, we obtained admission cTnT, angiography at the time of intervention, and cardiovascular magnetic resonance after 3 days. RESULTS: Elevated admission cTnT was associated with a higher corrected Thrombolysis In Myocardial Infarction frame count (P = 0.04) and with a trend toward worse myocardial blush grade at the end of the procedure (P = 0.069), indicating a higher degree of microvascular obstruction. This was confirmed by its correlation with the size of perfusion defect seen at first-pass cardiovascular magnetic resonance (ρ = 0.42, P = 0.028). In contrast, admission cTnT did not correlate with the amount of muscle necrosis as seen by delayed-enhancement cardiovascular magnetic resonance (ρ = 0.12, P = 0.55). CONCLUSION: Elevated admission cTnT predicts worse microvascular function in ST-elevation myocardial infarction patients managed with emergency percutaneous coronary intervention. Measuring admission cTnT might provide the interventionalist with useful information for selecting additional therapies that benefit coronary microcirculation. © 2009 Italian Federation of Cardiology.
Lingua originaleEnglish
pagine (da-a)664-668
Numero di pagine5
RivistaJournal of Cardiovascular Medicine
Volume10
DOI
Stato di pubblicazionePubblicato - 2009

Keywords

  • Aged
  • Angioplasty, Balloon, Coronary
  • Cohort Studies
  • Coronary Circulation
  • Coronary angiography
  • Female
  • Humans
  • MRI
  • Magnetic Resonance Angiography
  • Male
  • Microcirculation
  • Middle Aged
  • Myocardial Infarction
  • Patient Admission
  • Predictive Value of Tests
  • Recovery of Function
  • Retrospective Studies
  • Treatment Outcome
  • Troponin T

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