Electrical stimulation of the frontal cortex enhances slow-frequency EEG activity and sleepiness

Marcello Gorgoni, Paolo Maria Rossini, A. D'Atri, E. De Simoni, M. Gorgoni, M. Ferrara, F. Ferlazzo, L. De Gennaro

Risultato della ricerca: Contributo in rivistaArticolo in rivista

15 Citazioni (Scopus)

Abstract

Our aim was to enhance the spontaneous slow-frequency EEG activity during the resting state using oscillating transcranial direct currents (tDCS) with a stimulation frequency that resembles the spontaneous oscillations of sleep onset. Accordingly, in this preliminary study, we assessed EEG after-effects of a frontal oscillatory tDCS with different frequency (0.8 vs. 5 Hz) and polarity (anodal, cathodal, and sham).Two single-blind experiments compared the after effects on the resting EEG of oscillatory tDCS [Exp. 1 = 0.8 Hz, 10 subjects (26.2 ± 2.5 years); Exp. 2 = 5 Hz, 10 subjects (27.4 ± 2.4 years)] by manipulating its polarity.EEG signals recorded (28 scalp derivations) before and after stimulation [slow oscillations (0.5-1 Hz), delta (1-4 Hz), theta (5-7 Hz), alpha (8-12 Hz), beta 1 (13-15 Hz) and beta 2 (16-24 Hz)] were compared between conditions as a function of polarity (anodal vs. cathodal vs. sham) and frequency of stimulation (0.8 vs. 5 Hz).We found a significant relative enhancement of the delta activity after the anodal tDCS at 5 Hz compared to that at 0.8 Hz. This increase, even though not reaching the statistical significance compared to sham, is concomitant to a significant increase of subjective sleepiness, as assessed by a visual analog scale. These two phenomena are linearly related with a regional specificity, correlations being restricted to cortical areas perifocal to the stimulation site.We have shown that a frontal oscillating anodal tDCS at 5 Hz results in an effective change of both subjective sleepiness and spontaneous slow-frequency EEG activity. These changes are critically associated to both stimulation polarity (anodal) and frequency (5 Hz). However, evidence of frequency-dependence seems more unequivocal than evidence of polarity-dependence.
Lingua originaleEnglish
pagine (da-a)119-130
Numero di pagine12
RivistaNeuroscience
Volume324
DOI
Stato di pubblicazionePubblicato - 2016

Keywords

  • Adolescent
  • Adult
  • Delta Rhythm
  • EEG synchronization
  • Electroencephalography
  • Female
  • Frontal Lobe
  • Frontal cortex
  • Humans
  • Linear Models
  • Neuroscience (all)
  • Oscillatory transcranial direct current stimulation (osc-tDCS)
  • Polysomnography
  • Rest
  • Resting EEG
  • Single-Blind Method
  • Sleep
  • Sleep onset
  • Sleepiness
  • Transcranial Direct Current Stimulation
  • Young Adult

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