Elective-high frequency oscillatory ventilation in preterm infants with respiratory distress syndrome: an individual patients data meta-analysis

Giovanni Vento, Valentina Vendettuoli, Filip Cools, Lisa Askie, Martin Offringa, Jeanette Asselin, Sandra Calvert, Sherry Courtney, Carlo Dani, David Durand, Dale Gerstmann, David Henderson Smart, Neil Marlow, Janet Peacock, Jane Pillow, Roger Soll, Ulrich Thome, Patrick Truffert, Michael Schreiber, Patrick Van Reempts

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

[Fr:]BACKGROUND: Population and study design heterogeneity has confounded previous meta-analyses, leading to uncertainty about effectiveness and safety of elective high-frequency oscillatory ventilation (HFOV) in preterm infants. We assessed effectiveness of elective HFOV versus conventional ventilation in this group. METHODS: We did a systematic review and meta-analysis of individual patients' data from 3229 participants in ten randomised controlled trials, with the primary outcomes of death or bronchopulmonary dysplasia at 36 weeks' postmenstrual age, death or severe adverse neurological event, or any of these outcomes. FINDINGS: For infants ventilated with HFOV, the relative risk of death or bronchopulmonary dysplasia at 36 weeks' postmenstrual age was 0.95 (95% CI 0.88-1.03), of death or severe adverse neurological event 1.00 (0.88-1.13), or any of these outcomes 0.98 (0.91-1.05). No subgroup of infants (eg, gestational age, birthweight for gestation, initial lung disease severity, or exposure to antenatal corticosteroids) benefited more or less from HFOV. Ventilator type or ventilation strategy did not change the overall treatment effect. INTERPRETATION: HFOV seems equally effective to conventional ventilation in preterm infants. Our results do not support selection of preterm infants for HFOV on the basis of gestational age, birthweight for gestation, initial lung disease severity, or exposure to antenatal corticosteroids. FUNDING: Nestlé Belgium, Belgian Red Cross, and Dräger International.
Lingua originaleEnglish
pagine (da-a)2082-2091
Numero di pagine10
RivistaThe Lancet
Stato di pubblicazionePubblicato - 2010

Keywords

  • IP meta-analysis

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