TY - JOUR
T1 - Eight-year survival of a recurrent glioblastoma patient treated with molecularly tailored therapy: a case report
AU - D'Alessandris, Quintino Giorgio
AU - Montano, Nicola
AU - Martini, Maurizio
AU - Cenci, Tonia
AU - Lauretti, Liverana
AU - Pignotti, Fabrizio
AU - Olivi, Alessandro
AU - Fernandez Marquez, Eduardo Marcos
AU - Larocca, Luigi Maria
AU - Pallini, Roberto
PY - 2018
Y1 - 2018
N2 - Treatment options for recurrent glioblastoma are scarce; targeted therapy trials were disappointing, probably due to enrollment of patients without molecular selection. We treated with bevacizumab and erlotinib a 66-year-old male suffering from recurrent glioblastoma, IDH-wildtype and MGMT unmethylated, after three neurosurgeries. Treatment was tailored on molecular profile of recurrent tumor-namely, EGFRvIII positivity, VEGF overexpression, normal PTEN, low total VEGF and VEGF-121 mRNA-and resulted in complete, exceptionally durable response (51-month progression-free survival). Notably, histology of further recurrence after therapy was reminiscent of sarcoma. We suggest a thorough molecular screening for personalization of targeted therapy in recurrent glioblastoma
AB - Treatment options for recurrent glioblastoma are scarce; targeted therapy trials were disappointing, probably due to enrollment of patients without molecular selection. We treated with bevacizumab and erlotinib a 66-year-old male suffering from recurrent glioblastoma, IDH-wildtype and MGMT unmethylated, after three neurosurgeries. Treatment was tailored on molecular profile of recurrent tumor-namely, EGFRvIII positivity, VEGF overexpression, normal PTEN, low total VEGF and VEGF-121 mRNA-and resulted in complete, exceptionally durable response (51-month progression-free survival). Notably, histology of further recurrence after therapy was reminiscent of sarcoma. We suggest a thorough molecular screening for personalization of targeted therapy in recurrent glioblastoma
KW - targeted therapy
KW - targeted therapy
UR - http://hdl.handle.net/10807/130542
U2 - 10.1007/s00701-018-3697-3
DO - 10.1007/s00701-018-3697-3
M3 - Article
SN - 0001-6268
SP - 2387
EP - 2391
JO - Acta Neurochirurgica
JF - Acta Neurochirurgica
ER -