Efficient Inactivation of Clinically Relevant Antimicrobial Drug Concentrations by BacT/Alert or Bactec Resin-Containing Media in Simulated Adult Blood Cultures

Giulia Menchinelli; Flora Marzia Liotti; Liliana Giordano; Giulia De Angelis; Maurizio Sanguinetti; Teresa Spanu; Brunella Posteraro

doi:10.1128/AAC.00420-19

Efficient Inactivation of Clinically Relevant Antimicrobial Drug Concentrations by BacT/Alert or Bactec Resin-Containing Media in Simulated Adult Blood Cultures

Giulia Menchinelli, Flora Marzia Liotti, Liliana Giordano, Giulia De Angelis, Maurizio Sanguinetti^*, Teresa Spanu, Brunella Posteraro

^*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

4 Citazioni (Scopus)

Abstract

We assessed the antimicrobial-inactivation capability of BacT/Alert (FA Plus and FN Plus) or Bactec (Plus Aerobic/F and Plus Anaerobic/F) media for 40 antibiotic-bacterium combinations in simulated adult blood cultures. Aside from high recovery rates (93.2% and 88.4%, respectively), we showed that at the lowest but clinically relevant antibiotic concentrations, both BacT/Alert and Bactec media recovered all the organisms tested with drugs except for Escherichia coli, which was tested in the presence of meropenem. Delayed recoveries were mainly associated with vancomycin.

Lingua originale	English
pagine (da-a)	1-10
Numero di pagine	10
Rivista	Antimicrobial Agents and Chemotherapy
Volume	2019/63
DOI	https://doi.org/10.1128/AAC.00420-19
Stato di pubblicazione	Pubblicato - 2019

Keywords

NEUTRALIZATION OF ANTIMICROBIALS

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10.1128/AAC.00420-19

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title = "Efficient Inactivation of Clinically Relevant Antimicrobial Drug Concentrations by BacT/Alert or Bactec Resin-Containing Media in Simulated Adult Blood Cultures",

abstract = "We assessed the antimicrobial-inactivation capability of BacT/Alert (FA Plus and FN Plus) or Bactec (Plus Aerobic/F and Plus Anaerobic/F) media for 40 antibiotic-bacterium combinations in simulated adult blood cultures. Aside from high recovery rates (93.2% and 88.4%, respectively), we showed that at the lowest but clinically relevant antibiotic concentrations, both BacT/Alert and Bactec media recovered all the organisms tested with drugs except for Escherichia coli, which was tested in the presence of meropenem. Delayed recoveries were mainly associated with vancomycin.",

keywords = "NEUTRALIZATION OF ANTIMICROBIALS, NEUTRALIZATION OF ANTIMICROBIALS",

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year = "2019",

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language = "English",

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Efficient Inactivation of Clinically Relevant Antimicrobial Drug Concentrations by BacT/Alert or Bactec Resin-Containing Media in Simulated Adult Blood Cultures. / Menchinelli, Giulia; Liotti, Flora Marzia; Giordano, Liliana et al.
In: Antimicrobial Agents and Chemotherapy, Vol. 2019/63, 2019, pag. 1-10.

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

TY - JOUR

T1 - Efficient Inactivation of Clinically Relevant Antimicrobial Drug Concentrations by BacT/Alert or Bactec Resin-Containing Media in Simulated Adult Blood Cultures

AU - Menchinelli, Giulia

AU - Liotti, Flora Marzia

AU - Giordano, Liliana

AU - De Angelis, Giulia

AU - Sanguinetti, Maurizio

AU - Spanu, Teresa

AU - Posteraro, Brunella

PY - 2019

Y1 - 2019

N2 - We assessed the antimicrobial-inactivation capability of BacT/Alert (FA Plus and FN Plus) or Bactec (Plus Aerobic/F and Plus Anaerobic/F) media for 40 antibiotic-bacterium combinations in simulated adult blood cultures. Aside from high recovery rates (93.2% and 88.4%, respectively), we showed that at the lowest but clinically relevant antibiotic concentrations, both BacT/Alert and Bactec media recovered all the organisms tested with drugs except for Escherichia coli, which was tested in the presence of meropenem. Delayed recoveries were mainly associated with vancomycin.

AB - We assessed the antimicrobial-inactivation capability of BacT/Alert (FA Plus and FN Plus) or Bactec (Plus Aerobic/F and Plus Anaerobic/F) media for 40 antibiotic-bacterium combinations in simulated adult blood cultures. Aside from high recovery rates (93.2% and 88.4%, respectively), we showed that at the lowest but clinically relevant antibiotic concentrations, both BacT/Alert and Bactec media recovered all the organisms tested with drugs except for Escherichia coli, which was tested in the presence of meropenem. Delayed recoveries were mainly associated with vancomycin.

KW - NEUTRALIZATION OF ANTIMICROBIALS

UR - http://hdl.handle.net/10807/154499

U2 - 10.1128/AAC.00420-19

DO - 10.1128/AAC.00420-19

M3 - Article

SN - 1098-6596

VL - 2019/63

SP - 1

EP - 10

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

ER -

Efficient Inactivation of Clinically Relevant Antimicrobial Drug Concentrations by BacT/Alert or Bactec Resin-Containing Media in Simulated Adult Blood Cultures

Abstract

Keywords

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