TY - JOUR
T1 - Efficient Inactivation of Clinically Relevant Antimicrobial Drug Concentrations by BacT/Alert or Bactec Resin-Containing Media in Simulated Adult Blood Cultures
AU - Menchinelli, Giulia
AU - Liotti, Flora Marzia
AU - Giordano, Liliana
AU - De Angelis, Giulia
AU - Sanguinetti, Maurizio
AU - Spanu, Teresa
AU - Posteraro, Brunella
PY - 2019
Y1 - 2019
N2 - We assessed the antimicrobial-inactivation capability of BacT/Alert (FA Plus and FN Plus) or Bactec (Plus Aerobic/F and Plus Anaerobic/F) media for 40
antibiotic-bacterium combinations in simulated adult blood cultures. Aside from
high recovery rates (93.2% and 88.4%, respectively), we showed that at the lowest
but clinically relevant antibiotic concentrations, both BacT/Alert and Bactec media
recovered all the organisms tested with drugs except for Escherichia coli, which was
tested in the presence of meropenem. Delayed recoveries were mainly associated
with vancomycin.
AB - We assessed the antimicrobial-inactivation capability of BacT/Alert (FA Plus and FN Plus) or Bactec (Plus Aerobic/F and Plus Anaerobic/F) media for 40
antibiotic-bacterium combinations in simulated adult blood cultures. Aside from
high recovery rates (93.2% and 88.4%, respectively), we showed that at the lowest
but clinically relevant antibiotic concentrations, both BacT/Alert and Bactec media
recovered all the organisms tested with drugs except for Escherichia coli, which was
tested in the presence of meropenem. Delayed recoveries were mainly associated
with vancomycin.
KW - NEUTRALIZATION OF ANTIMICROBIALS
KW - NEUTRALIZATION OF ANTIMICROBIALS
UR - http://hdl.handle.net/10807/154499
U2 - 10.1128/AAC.00420-19
DO - 10.1128/AAC.00420-19
M3 - Article
SN - 1098-6596
VL - 2019/63
SP - 1
EP - 10
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
ER -