Efficacy of Modified Atkins Ketogenic Diet in Chronic Cluster Headache: An Open-Label, Single-Arm, Clinical Trial

Maurizio Evangelista, Paolo Rossi, Cherubino Di Lorenzo, Gianluca Coppola, Davide Di Lenola, Giulio Sirianni, Giorgio Di Lorenzo, Mariano Serrao, Francesco Pierelli

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

14 Citazioni (Scopus)

Abstract

Introduction: Drug-resistant cluster headache (CH) is still an open clinical challenge. Recently, our group observed the clinical efficacy of a ketogenic diet (KD), usually adopted to treat drug-resistant epilepsies, on migraine. Aim: Here, we aim to detect the effect of KD in a group of drug-resistant chronic CH (CCH) patients. Materials and methods: Eighteen drug-resistant CCH patients underwent a 12-week KD (Modified Atkins Diet, MAD), and the clinical response was evaluated in terms of response (≥50% attack reduction). Results: Of the 18 CCH patients, 15 were considered responders to the diet (11 experienced a full resolution of headache, and 4 had a headache reduction of at least 50% in terms of mean monthly number of attacks during the diet). The mean monthly number of attacks for each patient at the baseline was 108.71 (SD = 81.71); at the end of the third month of diet, it was reduced to 31.44 (SD = 84.61). Conclusion: We observed for the first time that a 3-month ketogenesis ameliorates clinical features of CCH. Clinical Trial Registration: www.ClinicalTrials.gov, identifier NCT03244735.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaFrontiers in Neurology
Volume9
DOI
Stato di pubblicazionePubblicato - 2018

Keywords

  • cluster headaches
  • drug resistance
  • ketogenesis
  • ketogenic diet
  • ketone bodies
  • modified Atkins diet

Fingerprint

Entra nei temi di ricerca di 'Efficacy of Modified Atkins Ketogenic Diet in Chronic Cluster Headache: An Open-Label, Single-Arm, Clinical Trial'. Insieme formano una fingerprint unica.

Cita questo