Efficacy and tolerability of lamivudine plus dolutegravir compared with lamivudine plus boosted PIs in HIV-1 positive individuals with virologic suppression: A retrospective study from the clinical practice

Francesca Lombardi, Gianmaria Baldin, Arturo Ciccullo, Davide Moschese, Arianna Emiliozzi, Elena Visconti, Andrea De Luca, Simona Di Giambenedetto

Risultato della ricerca: Contributo in rivistaArticolo in rivista

8 Citazioni (Scopus)

Abstract

Background: Direct comparisons between lamivudine plus bPIs and lamivudine plus dolutegravir as maintenance strategies in virologically-suppressed HIV positive patients are lacking. Methods: Time to treatment discontinuation (TD) and virological failure (VF) were compared in a cohort of HIV+ patients on a virologically-effective ART starting lamivudine with either darunavir/r, atazanavir/r or dolutegravir. Changes in laboratory parameters were also evaluated. Results: Four-hundred-ninety-four patients were analyzed (170 switching to darunavir/r, 141 to atazanavir/r, 183 to dolutegravir): median age was 49 years, with 8 years since ART start. Groups differed for age, HIV-risk factor, time since HIV-diagnosis and on ART, previous therapy and reasons for switching. Estimated proportions free from TD at week 48 and 96 were 79.8 and 48.3% of patients with darunavir/r, 87.0 and 70.9% with atazanavir/r, and 88.2 and 82.6% with dolutegravir, respectively (p < 0.001). Calendar years, HIV-risk factor, higher baseline cholesterol and an InSTI-based previous regimen predicted TD, whereas lamivudine+dolutegravir therapy and previous tenofovir use were protective. VF was the cause of TD in 6/123 cases with darunavir/r, 4/97 with atazanavir/r and 3/21 with dolutegravir. Other main reasons for TD were: toxicity (43.1% with darunavir/r, 39.2% with atazanavir/r, 52.4% with dolutegravir), further simplification (36.6% with darunavir/r, 30.9% with atazanavir/r, 14.3% with dolutegravir). Incidence of VF did not differ among study groups (p = 0.747). No factor could predict VF. Lipid profile improved in the dolutegravir group, whereas renal function improved in the bPIs groups. Conclusions: In real practice, a switch to lamivudine+dolutegravir showed similar efficacy but longer durability than a switch to lamivudine+bPIs.
Lingua originaleEnglish
pagine (da-a)59-60
Numero di pagine2
RivistaBMC Infectious Diseases
Volume19
DOI
Stato di pubblicazionePubblicato - 2019

Keywords

  • Adult
  • Anti-HIV Agents
  • Antiretroviral Therapy, Highly Active
  • Antiretroviral therapy
  • Atazanavir Sulfate
  • Atazanavir/ritonavir
  • Cohort Studies
  • Darunavir
  • Darunavir/ritonavir
  • Dolutegravir
  • Drug Therapy, Combination
  • Dual therapy
  • Female
  • HIV
  • HIV Infections
  • HIV Seropositivity
  • HIV-1
  • Heterocyclic Compounds, 3-Ring
  • Humans
  • Lamivudine
  • Maintenance therapy
  • Male
  • Middle Aged
  • Retrospective Studies
  • Ritonavir
  • Tenofovir
  • Treatment Outcome
  • Viral Load

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