TY - JOUR
T1 - Efficacy and Tolerability of Brevilin-A, a Natural JAK Inhibitor, in Pediatric Alopecia Areata: A Case Series
AU - Matteini, E.
AU - Diluvio, L.
AU - Lambiase, S.
AU - Cioni, A.
AU - Shumak, R. G.
AU - Costanza, G.
AU - Lanna, C.
AU - Caldarola, Giacomo
AU - Bianchi, L.
AU - Campione, E.
PY - 2024
Y1 - 2024
N2 - Alopecia areata represents an autoimmune disease that specifically damages growing hair follicles on the scalp and/or around the body. Janus kinase inhibitors have been identified as an effective therapy in adult patients and topical formulations, such as Brevilin-A, might represent a well-tolerated treatment for mild-moderate disease in children and adolescents. The mechanism of action of Brevilin-A, a sesquiterpene lactone isolated from Centipeda minima, could consist in blocking STAT3 and STAT1 signaling as well as the JAKs activity by inhibiting the JAKs tyrosine kinase domain JH1. We report our cases of successful application of Brevilin-A in pediatric patients, suggesting this treatment as a safe and effective therapeutic option also for recalcitrant alopecia areata in pediatric population.
AB - Alopecia areata represents an autoimmune disease that specifically damages growing hair follicles on the scalp and/or around the body. Janus kinase inhibitors have been identified as an effective therapy in adult patients and topical formulations, such as Brevilin-A, might represent a well-tolerated treatment for mild-moderate disease in children and adolescents. The mechanism of action of Brevilin-A, a sesquiterpene lactone isolated from Centipeda minima, could consist in blocking STAT3 and STAT1 signaling as well as the JAKs activity by inhibiting the JAKs tyrosine kinase domain JH1. We report our cases of successful application of Brevilin-A in pediatric patients, suggesting this treatment as a safe and effective therapeutic option also for recalcitrant alopecia areata in pediatric population.
KW - alopecia areata
KW - brevelin A
KW - pediatric
KW - topical JAK inhibitors
KW - alopecia areata
KW - brevelin A
KW - pediatric
KW - topical JAK inhibitors
UR - https://publicatt.unicatt.it/handle/10807/299920
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85207021201&origin=inward
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85207021201&origin=inward
U2 - 10.2147/CCID.S461557
DO - 10.2147/CCID.S461557
M3 - Article
SN - 1178-7015
VL - 17
SP - 2225
EP - 2230
JO - Clinical, Cosmetic and Investigational Dermatology
JF - Clinical, Cosmetic and Investigational Dermatology
IS - 2024
ER -
