Efficacy and safety of Vismodegib treatment in patients with advanced basal cell carcinoma and multiple comorbidities

Alfredo Piccerillo, Ketty Peris, Maria Concetta Fargnoli, Giulia Spallone, Alessandra Ventura, Maria C. Fargnoli, Carlota Gutierrez, Sara Tambone, Luca Bianchi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

3 Citazioni (Scopus)

Abstract

Basal cell carcinoma (BCC) is the most common malignancy in Caucasians, and its incidence is increasing. Most BCCs are treated surgically, nevertheless surgery is not an effective treatment for locally advanced or metastatic BCC. Alterations in hedgehog signaling pathway, a key regulator of cell growth and differentiation during development, are implicated in the pathogenesis of basal-cell carcinoma. Vismodegib is a small-molecule inhibitor of smoothened (SMO), a key component of the hedgehog (Hh) signaling pathway, administered in BCC patients, especially when surgery and radiotherapy treatments have failed. We report a series of eight elderly patients treated with vismodegib for advanced BCC and affected by concomitant multiple comorbidities. The efficacy and tolerability of vismodegib in patients with single and/or multiple comorbidities has been poorly studied. In our observation an overall high safety and tolerability has been observed over the course of treatment, with side effects of grade I and II and no changes in vital parameters, electrocardiography and echocardiogram. Vismodegib has been shown to be a safe and well tolerated treatment option for elderly patients affected by multiple comorbidities and advanced BCC.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaDermatologic Therapy
Volume32
DOI
Stato di pubblicazionePubblicato - 2019

Keywords

  • basal cell carcinoma
  • comorbidities
  • safety
  • vismodegib

Fingerprint

Entra nei temi di ricerca di 'Efficacy and safety of Vismodegib treatment in patients with advanced basal cell carcinoma and multiple comorbidities'. Insieme formano una fingerprint unica.

Cita questo