Effects of vagus nerve stimulation on cortical excitability in epileptic patients

Vincenzo Di Lazzaro; A Oliviero; Fabio Pilato; Eleonora Saturno; M Dileone; Mario Meglio; Gabriella Colicchio; C Barba; Fabio Papacci; Pa Tonali

Effects of vagus nerve stimulation on cortical excitability in epileptic patients

Vincenzo Di Lazzaro, A Oliviero, Fabio Pilato, Eleonora Saturno, M Dileone, Mario Meglio, Gabriella Colicchio, C Barba, Fabio Papacci, Pa Tonali

Risultato della ricerca: Contributo in rivista › Articolo in rivista

57 Citazioni (Scopus)

Abstract

Vagus nerve stimulation (VNS) is used as adjunctive treatment for medically refractory epilepsy, but little is known about its mechanisms of action. The effects of VNS on the excitatory and inhibitory circuits of the motor cortex were evaluated in five patients with epilepsy using single- and paired-pulse transcranial magnetic stimulation (TMS). Patients were examined with the stimulator on and off. VNS determined a selective and pronounced increase in the inhibition produced by paired-pulse TMS with no effects on the excitability by single-pulse TMS.

Lingua originale	English
pagine (da-a)	2310-2312
Numero di pagine	3
Rivista	Neurology
Volume	62
Stato di pubblicazione	Pubblicato - 2004

Keywords

Adult
Epilepsy
Female
Humans
Magnetics
Male
Middle Aged
Motor Cortex
Physical Therapy Modalities
Vagus Nerve

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abstract = "Vagus nerve stimulation (VNS) is used as adjunctive treatment for medically refractory epilepsy, but little is known about its mechanisms of action. The effects of VNS on the excitatory and inhibitory circuits of the motor cortex were evaluated in five patients with epilepsy using single- and paired-pulse transcranial magnetic stimulation (TMS). Patients were examined with the stimulator on and off. VNS determined a selective and pronounced increase in the inhibition produced by paired-pulse TMS with no effects on the excitability by single-pulse TMS.",

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TY - JOUR

T1 - Effects of vagus nerve stimulation on cortical excitability in epileptic patients

AU - Di Lazzaro, Vincenzo

AU - Oliviero, A

AU - Pilato, Fabio

AU - Saturno, Eleonora

AU - Dileone, M

AU - Meglio, Mario

AU - Colicchio, Gabriella

AU - Barba, C

AU - Papacci, Fabio

AU - Tonali, Pa

PY - 2004

Y1 - 2004

N2 - Vagus nerve stimulation (VNS) is used as adjunctive treatment for medically refractory epilepsy, but little is known about its mechanisms of action. The effects of VNS on the excitatory and inhibitory circuits of the motor cortex were evaluated in five patients with epilepsy using single- and paired-pulse transcranial magnetic stimulation (TMS). Patients were examined with the stimulator on and off. VNS determined a selective and pronounced increase in the inhibition produced by paired-pulse TMS with no effects on the excitability by single-pulse TMS.

AB - Vagus nerve stimulation (VNS) is used as adjunctive treatment for medically refractory epilepsy, but little is known about its mechanisms of action. The effects of VNS on the excitatory and inhibitory circuits of the motor cortex were evaluated in five patients with epilepsy using single- and paired-pulse transcranial magnetic stimulation (TMS). Patients were examined with the stimulator on and off. VNS determined a selective and pronounced increase in the inhibition produced by paired-pulse TMS with no effects on the excitability by single-pulse TMS.

KW - Adult

KW - Epilepsy

KW - Female

KW - Humans

KW - Magnetics

KW - Male

KW - Middle Aged

KW - Motor Cortex

KW - Physical Therapy Modalities

KW - Vagus Nerve

KW - Adult

KW - Epilepsy

KW - Female

KW - Humans

KW - Magnetics

KW - Male

KW - Middle Aged

KW - Motor Cortex

KW - Physical Therapy Modalities

KW - Vagus Nerve

UR - http://hdl.handle.net/10807/34008

M3 - Article

SN - 0028-3878

VL - 62

SP - 2310

EP - 2312

JO - Neurology

JF - Neurology

ER -

Effects of vagus nerve stimulation on cortical excitability in epileptic patients

Abstract

Keywords

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