Effects of tumor necrosis factor-α inhibitors in mothers and daughters concordant for HLA-B27-positive ankylosing spondylitis

Donato Rigante, Francesco Caso, Luisa Costa, Antonio Del Puente, Carlo Selmi, Marta Fabbroni, Raffaele Scarpa, Mauro Galeazzi, Bruno Frediani, Luca Cantarini

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

1 Citazioni (Scopus)

Abstract

OBJECTIVES: Pharmacogenomics is considered as the new frontier to predict the response to treatments and it can also be based on the comparison of family members being treated for the same condition. No data are available on the impact of anti-tumour necrosis factor (TNF)-α therapies in members of the same family with ankylosing spondylitis (AS). METHODS: We describe three mother-daughter couples concordant for AS and HLA-B27, both treated with TNF-α inhibitors, for whom the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), and Ankylosing Spondylitis Disease Activity Score (ASDAS)-CRP were evaluated during a follow-up of 24 months. RESULTS: All patients manifested improvements of all scores, but the daughters had a more prominent effect achieving faster complete disease remission. CONCLUSIONS: We hypothesise that longer standing chronic inflammation and older age may cause a less prompt and effective response to treatment in SA when compared with their genetically related controls.
Lingua originaleEnglish
pagine (da-a)411-413
Numero di pagine3
RivistaCLINICAL AND EXPERIMENTAL RHEUMATOLOGY
Volume2015
Stato di pubblicazionePubblicato - 2015

Keywords

  • Spondyloarthritis

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