Effects of the administration of epidermal growth factor receptor specific inhibitor cetuximab, alone and in combination with cisplatin, on proliferation and apoptosis of Hep-2 laryngeal cancer cells

Giacomo Pozzoli, Gaetano Paludetti, Pierluigi Navarra, Giovanni Almadori, Francesco Bussu, Veronica Giglia, Davide Rizzo, Attilio Limongelli, Eugenio De Corso, Cristina Graziani

Risultato della ricerca: Contributo in rivistaArticolo in rivista

5 Citazioni (Scopus)

Abstract

Epidermal growth factor receptor (EGFR) overexpression and prognostic value in head and neck squamous cell cancer is the basis for targeting by anti-EGFR antibodies, which increase the efficacy of radiotherapy. In order to evaluate the best therapeutic schedule, the effects of cetuximab (C225) on Hep-2 cell proliferation, alone and in combination with cisplatin, were studied.
Lingua originaleEnglish
pagine (da-a)902-908
Numero di pagine7
RivistaJournal of Laryngology and Otology
Volume128
DOI
Stato di pubblicazionePubblicato - 2014

Keywords

  • EGFR
  • Hep-2
  • Laryngeal Cancer
  • cisplatin

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