Abstract
Oxidative stress is involved both in metabolic
syndrome and male infertility. Hypogonadism is also associated
with increased risk for cardiovascular disease. To investigate the role
of gonadal steroids in systemic antioxidant regulation, we determined
plasma CoenzymeQ10 (CoQ10) and total antioxidant capacity
(TAC) in postsurgical hypopituitaric patients. Twenty-six patients
aged 28 55 years were studied 6 12 months after surgery. CoQ10
levels were measured by high-performance liquid chromatography
and TAC by spectroscopy with the use of the mioglobin-H2O2
system, which, in interacting with chromogen 2,2I-azinobis-(3-
ethylbenzothiazoline-6-sulfonate), generates a radical after a latency
time (LAG) that is proportional to antioxidant content. Sixteen
patients presented low testosterone values; in 10 patients hypogonadism
was isolated, and in 6 patients hypothyroidism also was
present. CoQ10 levels were significantly lower in isolated hypogonadism
than in normogonadism. Testosterone treatment, performed
in those patients with isolated hypogonadism, induced a significant
enhancement both in CoQ10 level and LAG. CoQ10 and LAG values
correlated significantly, suggesting an interrelationship between
different antioxidants. Our data suggest that hypogonadism could
represent a condition of oxidative stress, in turn related with
augmented cardiovascular risk.
Lingua originale | English |
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pagine (da-a) | 622-629 |
Numero di pagine | 8 |
Rivista | Journal of Andrology |
Stato di pubblicazione | Pubblicato - 2008 |
Keywords
- ANDROGEN
- COENZYME Q10
- OXIDATIVE STRESS
- TOTAL ANTIOXIDANT CAPACITY