Effects of Switching from Twice-Daily to Once-Daily Tacrolimus Formulation on Quality of Life, Anxiety, and Transplant Benefit Perception after Kidney Transplantation

Jacopo Romagnoli, Franco Citterio, Rosaria Calia, Carlo Lai, Paola Aceto, Massimiliano Luciani, Antonio Gargiulo, S Lai

Risultato della ricerca: Contributo in rivistaArticolo in rivista

15 Citazioni (Scopus)

Abstract

Objective. This study investigated whether switching from the twice-daily (Prograf; TAC) to the once-daily formulation of tacrolimus with extended release (Advagraf; XL) affected quality of life, anxiety, and transplant benefit perception after allogeneic kidney transplantation. Methods. After local Institutional Review Board approval, 78 adult patients prescribed twice-daily tacrolimus for >= 1 year after kidney transplantation were asked to participate in this study. All patients were evaluated at T0 (before the switch), and the 49 who accepted the change were reassessed after 6 months (T1). The following tests were used: (State and Trait Anxiety Inventories Y1 and Y2, (Psychologic General Well-Being Index), and modified Transplant Effect Questionnaire for posttransplantation symptoms. Blood samples for laboratory profiles and determinations of drug concentrations were obtained throughout the study period. Results. There were no significant differences between the psychologic variables at TO among patients who switched from TAC to XL (n = 49) versus those who did not participate (n = 29). Eight of the 49 patients who accepted the drug conversion were reswitched to TAC because of adverse events. At T1, the remaining switched patients (n = 41) showed an increase in the disclosure of having undergone transplantation (P < .05) versus nonswitched patients; whereas reswitched patients (n = 8) showed less positivity and well-being (P < .05) compared with those who remained in the switched regimen. Conclusion. The findings suggested increased disclosure of having undergone transplantation among patients who decided to switch from TAC to XL.
Lingua originaleEnglish
pagine (da-a)1020-1023
Numero di pagine4
RivistaTransplantation Proceedings
Volume43
DOI
Stato di pubblicazionePubblicato - 2011

Keywords

  • transplantation

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