Effects of surgical treatment in thymoma with myasthenia gravis: our experience in 103 patients

F Crucitti, Gb Doglietto, Rocco Domenico Alfonso Bellantone, Vincenzo Perri, O Tommasini, Pietro Attilio Tonali

Risultato della ricerca: Contributo in rivistaArticolo in rivista

31 Citazioni (Scopus)


A retrospective study of 103 thymectomies examines the effects of the integration of surgical and medical therapy in patients affected by myasthenia gravis accompanied by thymoma. An extended thymectomy via a median longitudinal sternotomy was used in 102 patients. The operative mortality was 4.85% (5/103 patients), the 10-year survival rate was 78% with a recurrence rate of 3.06% (3/98). Neoplastic infiltration and postoperative radiotherapy did not influence the survival rate. There was no correlation between a preoperative Osserman's class better than III and postoperative outcome. The improvement of medical treatment, and anaesthesiological and intensive care techniques resulted in a decrease of the operative mortality and long-term death rate during the last 10 years of our 20-year series. Extended thymectomy via sternotomy is the best intervention in patients with myasthenia gravis associated with thymoma judged by the low operative mortality and the favorable 10-year survival rates.
Lingua originaleEnglish
pagine (da-a)43-46
Numero di pagine4
RivistaJournal of Surgical Oncology
Stato di pubblicazionePubblicato - 1992


  • Adolescent
  • Adrenal Cortex Hormones
  • Adult
  • Aged
  • Cholinesterase Inhibitors
  • Combined Modality Therapy
  • Female
  • Humans
  • Male
  • Middle Aged
  • Myasthenia Gravis
  • Retrospective Studies
  • Survival Analysis
  • Thymectomy
  • Thymoma
  • Thymus Neoplasms


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