Effects of subacute treatment with toluene on cerebrocortical alpha- and beta-adrenergic receptors in the rat. Evidence for an increased number and a reduced affinity of beta-adrenergic receptors

Maria Martire, K Fuxe, G Von Euler, Lf Agnati, T Hansson, K Andersson, Ja Gustafsson, A. Härfstrand

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

24 Citazioni (Scopus)

Abstract

Subacute treatment with toluene (80-1500 p.p.m.) produces a dose-dependent reduction of affinity and increase in density of the beta-adrenergic antagonist [3H]dihydroalprenolol binding sites in the frontoparietal cortex of the male rat, while the binding characteristics of alpha 1-adrenergic ([3H]WB 4101) and alpha 2-adrenergic ([3H]p-aminoclonidine) binding sites in the same region is unaffected by this treatment as evaluated in vitro. Therefore, it is suggested that the cortical beta-adrenergic receptors are particularly vulnerable to the action of toluene in vivo. It is speculated that as a result cortical beta-adrenergic neurotransmission may be altered following exposure to low concentrations of toluene, possibly related to the physico-chemical properties of toluene, leading to changes in membrane fluidity.
Lingua originaleEnglish
pagine (da-a)307-311
Numero di pagine5
RivistaActa Physiologica Scandinavica
Volume130
Stato di pubblicazionePubblicato - 1987

Keywords

  • Animals
  • Cerebral Cortex
  • Clonidine
  • Dihydroalprenolol
  • Dioxanes
  • Male
  • Rats
  • Rats, Inbred Strains
  • Receptors, Adrenergic, alpha
  • Receptors, Adrenergic, beta
  • Toluene

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