Abstract
Subacute treatment with toluene (80-1500 p.p.m.) produces a dose-dependent reduction of affinity and increase in density of the beta-adrenergic antagonist [3H]dihydroalprenolol binding sites in the frontoparietal cortex of the male rat, while the binding characteristics of alpha 1-adrenergic ([3H]WB 4101) and alpha 2-adrenergic ([3H]p-aminoclonidine) binding sites in the same region is unaffected by this treatment as evaluated in vitro. Therefore, it is suggested that the cortical beta-adrenergic receptors are particularly vulnerable to the action of toluene in vivo. It is speculated that as a result cortical beta-adrenergic neurotransmission may be altered following exposure to low concentrations of toluene, possibly related to the physico-chemical properties of toluene, leading to changes in membrane fluidity.
Lingua originale | Inglese |
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pagine (da-a) | 307-311 |
Numero di pagine | 5 |
Rivista | Acta Physiologica Scandinavica |
Volume | 130 |
Stato di pubblicazione | Pubblicato - 1987 |
Keywords
- Animals
- Cerebral Cortex
- Clonidine
- Dihydroalprenolol
- Dioxanes
- Male
- Rats
- Rats, Inbred Strains
- Receptors, Adrenergic, alpha
- Receptors, Adrenergic, beta
- Toluene