TY - JOUR
T1 - Effects of Sub-Acute Exposure to Rhodium (as Rh (III) chloride hydrate) on Cytokines in Female Wistar Rats
AU - Iavicoli, Ivo
AU - Sgambato, Alessandro
AU - Fontana, Luca
AU - Marinaccio, Alessandro
AU - Leso, Veruscka
AU - Corbi, Maddalena
AU - Bergamaschi, Antonio
AU - Calabrese, Edward J.
PY - 2012
Y1 - 2012
N2 - Quantitative changes in different cytokines were determined in serum of female Wistar rats exposed to Rhodium (III) chloride hydrate to evaluate its early effects on the immune system. Findings revealed an inhibitory effect of Rh salt since each cytokine, with the exceptions of IL-1α and IL-2 levels observed at the highest doses of exposure, was reduced compared to the controls and interestingly, the lowest doses induced the greatest inhibition. This generalized decrease of cytokine levels was not related to a specific cytokine pathway, and may suggest an anti-inflammatory role of Rh salt.
AB - Quantitative changes in different cytokines were determined in serum of female Wistar rats exposed to Rhodium (III) chloride hydrate to evaluate its early effects on the immune system. Findings revealed an inhibitory effect of Rh salt since each cytokine, with the exceptions of IL-1α and IL-2 levels observed at the highest doses of exposure, was reduced compared to the controls and interestingly, the lowest doses induced the greatest inhibition. This generalized decrease of cytokine levels was not related to a specific cytokine pathway, and may suggest an anti-inflammatory role of Rh salt.
KW - rhodium
KW - rhodium
UR - http://hdl.handle.net/10807/29517
U2 - 10.1007/s00128-012-0720-x
DO - 10.1007/s00128-012-0720-x
M3 - Article
SN - 0007-4861
VL - 89
SP - 686
EP - 692
JO - Bulletin of Environmental Contamination and Toxicology
JF - Bulletin of Environmental Contamination and Toxicology
ER -