Effects of sex and age on pyridostigmine potentiation of growth hormone-releasing hormone-induced growth hormone release

Salvatore Maria Corsello, Angelina Barini, Silvia Della Casa, Carlo Antonio Rota, Simonetta Colasanti, Antonino Barbarino, A Tofani, R Sciuto

Risultato della ricerca: Contributo in rivistaArticolo in rivista

7 Citazioni (Scopus)

Abstract

Previous studies have shown that pyridostigmine (PD) is capable of increasing the growth hormone (GH) response to GH-releasing hormone (GHRH) in young healthy subjects. In order to investigate the influence of age and sex on the PD potentiation of GHRH-induced GH release, we have studied the GH response to GHRH (50 micrograms i.v.) 1 h after oral administration of placebo or PD (60 mg) in 8 young healthy men (aged 19-28 years) and 8 age-matched young women (aged 18-25 years) during the follicular phase of the menstrual cycle, as well as in 8 postmenopausal women (aged 57-62 years) and 8 age-matched elderly men (aged 56-64 years). In the same subjects the effect of PD alone (60 mg p.o.) was also studied. Furthermore, in 6 postmenopausal women and 6 elderly men, the effect of a 30-mg PD oral dose on GH secretion and GH response to GHRH was evaluated with a similar protocol. The GH responses (mean +/- SE) to GHRH + placebo were similar in young men (peak 20.1 +/- 2 ng/ml, AUC 1,250 +/- 113 ng/ml/min) and women (peak 29.3 +/- 2.3 ng/ml, AUC 1,769 +/- 305 ng/ml/min). PD 60 mg was capable of significantly increasing the GH response to GHRH in young men (peak 43.5 +/- 5.1 ng/ml, AUC 3,734 +/- 472 ng/ml/min, p less than 0.005) but not in women (peak 39 +/- 2.3 ng/ml, AUC 2,479 +/- 205 ng/ml/min).(ABSTRACT TRUNCATED AT 250 WORDS)
Lingua originaleEnglish
pagine (da-a)208-213
Numero di pagine6
RivistaNeuroendocrinology
Volume56
Stato di pubblicazionePubblicato - 1992

Keywords

  • Adolescent
  • Adult
  • Aging
  • Drug Synergism
  • Female
  • Growth Hormone
  • Growth Hormone-Releasing Hormone
  • Humans
  • Kinetics
  • Male
  • Menopause
  • Middle Aged
  • Pyridostigmine Bromide
  • Sex Characteristics

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