Abstract Objective: To test the hypothesis that lutein, compared to the placebo, would enhance the total antioxidant status (TAS) in the preterm infants. Methods: Infants with gestational age ≤34 weeks were randomly assigned to receive a daily dose of lutein and zeaxanthin (0.5 mg + 0.02 mg/Kg/day) or placebo from the seventh day of life until 40th week of postmenstrual age or until discharge. Results: Seventy-seven preterm infants were randomized (38 in the Lutein group and 39 in the Placebo group) with mean gestational age of 30.4 (±2.3) weeks and the mean birth weight of 1415 (±457) grams. The TAS did not result statistically different between the two groups during all the study period, but a significant linear correlation was evidenced between plasma lutein concentration and TAS (r=0.14, p 0.012) and between plasma zeaxanthin concentration and TAS (r=0.13, p 0.02). Conclusions: Supplementation of preterm infants with orally lutein was ineffective in enhancing biological antioxidant capacity. Further studies need to better understand the bioavailability of lutein in the neonatal period in order to identify any best form of supplementation.
|Rivista||THE JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE|
|Stato di pubblicazione||Pubblicato - 2013|
- Preterm infants