Effects of Low-Dose Aspirin on Vascular Sensitivity to Angiotensin II and on 24 Hours Arterial Blood Pressure in Pregnancy

Sergio Ferrazzani, Sara De Carolis, Antonio Lanzone, Alessandro Caruso, Salvatore Mancuso

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

2 Citazioni (Scopus)

Abstract

The angiotensin sensitivity test (AST) was performed in a group of 40 high risk pregnant women before and after oral administration of low doses of aspirin (ASA) (100 mg). AST performed before ASA characterized two groups of patients: 18 with positive AST (AST+) (effective pressor dose (EPD) = 6.91±1.69 (mean ± S.D.) ng/Kg/min of angiotensin II (A II)) and 22 with negative AST (AST-) (EPD = 22.44±11.23 ng/Kg/min of All). After ASA administration there was a significant increase in EPD in AST+ patients (15.00±9.54 ng/Kg/min, p<0.001). In AST- patients the mean EPD was significantly but non-homogeneously changed (18.33±8.11 ng/Kg/min). Nineteen pregnant high risk patients also underwent AST between weeks 24 and 39 of gestation. Then systolic, diastolic and mean arterial blood pressure were recorded using a portable device for indirect noninvasive automatic arterial pressure measure before and after seven days of low-dose aspirin therapy. In AST- patients no significant difference was observed before and after ASA regimen, whereas in AST+ patients post ASA mean blood pressure values were lower than pre ASA values, and during nighttime this difference became significant.
Lingua originaleEnglish
pagine (da-a)171-188
Numero di pagine18
RivistaCLINICAL AND EXPERIMENTAL HYPERTENSION. PART B, HYPERTENSION IN PREGNANCY
DOI
Stato di pubblicazionePubblicato - 1988

Keywords

  • HYPERTENSION
  • LOW DOSE OF ASPIRIN
  • PREGNANCY

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