Effects of Italian Mediterranean organic diet vs. low-protein diet in nephropathic patients according to MTHFR genotypes

Pietro Manuel Ferraro, Nicola Di Daniele, Laura Di Renzo, Annalisa Noce, Leonardo Iacopino, Mariagiovanna Rizzo, Francesca Sarlo, Emidio Domino, Antonino De Lorenzo

Risultato della ricerca: Contributo in rivistaArticolo in rivista

29 Citazioni (Scopus)


Background: Several reports associate an Italian-style Mediterranean diet (IMD) with lower risk of cardiovascular disease and morbidity. The present study aimed to explore the effects of an Italian Mediterranean organic diet (IMOD) versus low-protein diet (LPD) in chronic kidney disease (CKD) patients, according to patients’ carrier status for the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism.Methods: A total of 40 male patients with CKD and stable renal function (Kidney Disease Outcomes Quality Initiative stages 2 and 3) were classified according to MTHFR polymorphism as carrier T(+) or non carrier T(−). At the time of enrolment (T0) patients’ diet consisted of LPD; they were then administered IMD for 14 days (T1), thereupon IMOD for 14 days (T2). Patients underwent a complete medical history, body composition assessment and biochemical analysis.Results: Baseline homocysteine levels were on average 8.24 mol/l higher (95 % confidence interval 6.47, 10.00) among T(+) than T(−) and the difference was statistically significant (p < 0.001). We found a significant interaction between MTHFR status and the effect of both the IMD and IMOD on homocysteine levels compared to LPD (p for interaction <0.001). Both the IMD and IMOD resulted in significant variations of anthropometric and laboratory measurements.Conclusions: IMD and IMOD diets could represent a viable alternative to LPD in CKD patients on conservative therapy. The effect of these diets seems to be influenced by MTHFR genotypes.
Lingua originaleEnglish
pagine (da-a)529-536
Numero di pagine8
Stato di pubblicazionePubblicato - 2014


  • Adult
  • Biomarkers
  • Body composition
  • C677T MTHFR polymorphism
  • Cardiovascular disease risk
  • Chronic kidney disease
  • Diet, Mediterranean
  • Diet, Protein-Restricted
  • Food, Organic
  • Genotype
  • Homocysteine
  • Humans
  • Italian Mediterranean organic diet
  • Male
  • Methylenetetrahydrofolate Reductase (NADPH2)
  • Middle Aged
  • Nephrology
  • Phenotype
  • Polymorphism, Genetic
  • Renal Insufficiency, Chronic
  • Time Factors
  • Treatment Outcome


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