Effects of ghrelin administration on endocrine and metabolic parameters in obese women with polycystic ovary syndrome

Alessandra Fusco; Antonio Bianchi; Antonio Mancini; Domenico Milardi; Antonella Giampietro; V Cimino; Teresa Porcelli; Daniela Romualdi; Maurizio Guido; Antonio Lanzone; Alfredo Pontecorvi; Laura De Marinis Grasso

Effects of ghrelin administration on endocrine and metabolic parameters in obese women with polycystic ovary syndrome

Alessandra Fusco, Antonio Bianchi, Antonio Mancini, Domenico Milardi, Antonella Giampietro, V Cimino, Teresa Porcelli, Daniela Romualdi, Maurizio Guido, Antonio Lanzone, Alfredo Pontecorvi, Laura De Marinis Grasso

Risultato della ricerca: Contributo in rivista › Articolo

26 Citazioni (Scopus)

Abstract

The novel peptide ghrelin displays multiple endocrine and non-endocrine actions. Its strong GH-releasing activity in humans has long been recognized. However, in obesity, ghrelin administration induces a blunted GH secretion, enhances glucose and reduces insulin levels. The effects of ghrelin administration have not been investigated in polycystic ovary syndrome (PCOS), which can be associated with obesity, hyperinsulinism, and GH hyposecretion. Leptin is a mediator for energy balance opposed to ghrelin; both of them are supposed to act as regulators of reproductive functions.

Lingua originale	Inglese
pagine (da-a)	948-956
Numero di pagine	9
Rivista	Journal of Endocrinological Investigation
Volume	30
Stato di pubblicazione	Pubblicato - 2007

Keywords

Adult
Blood Glucose
Fatty Acids, Nonesterified
Female
Ghrelin
Growth Hormone
Humans
Insulin
Leptin
Obesity
Polycystic Ovary Syndrome
Prolactin
Thyrotropin

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title = "Effects of ghrelin administration on endocrine and metabolic parameters in obese women with polycystic ovary syndrome",

abstract = "The novel peptide ghrelin displays multiple endocrine and non-endocrine actions. Its strong GH-releasing activity in humans has long been recognized. However, in obesity, ghrelin administration induces a blunted GH secretion, enhances glucose and reduces insulin levels. The effects of ghrelin administration have not been investigated in polycystic ovary syndrome (PCOS), which can be associated with obesity, hyperinsulinism, and GH hyposecretion. Leptin is a mediator for energy balance opposed to ghrelin; both of them are supposed to act as regulators of reproductive functions.",

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author = "Alessandra Fusco and Antonio Bianchi and Antonio Mancini and Domenico Milardi and Antonella Giampietro and V Cimino and Teresa Porcelli and Daniela Romualdi and Maurizio Guido and Antonio Lanzone and Alfredo Pontecorvi and {De Marinis Grasso}, Laura",

year = "2007",

language = "English",

volume = "30",

pages = "948--956",

journal = "Journal of Endocrinological Investigation",

issn = "1720-8386",

publisher = "Springer Science and Business Media Deutschland GmbH",

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TY - JOUR

T1 - Effects of ghrelin administration on endocrine and metabolic parameters in obese women with polycystic ovary syndrome

AU - Fusco, Alessandra

AU - Bianchi, Antonio

AU - Mancini, Antonio

AU - Milardi, Domenico

AU - Giampietro, Antonella

AU - Cimino, V

AU - Porcelli, Teresa

AU - Romualdi, Daniela

AU - Guido, Maurizio

AU - Lanzone, Antonio

AU - Pontecorvi, Alfredo

AU - De Marinis Grasso, Laura

PY - 2007

Y1 - 2007

N2 - The novel peptide ghrelin displays multiple endocrine and non-endocrine actions. Its strong GH-releasing activity in humans has long been recognized. However, in obesity, ghrelin administration induces a blunted GH secretion, enhances glucose and reduces insulin levels. The effects of ghrelin administration have not been investigated in polycystic ovary syndrome (PCOS), which can be associated with obesity, hyperinsulinism, and GH hyposecretion. Leptin is a mediator for energy balance opposed to ghrelin; both of them are supposed to act as regulators of reproductive functions.

AB - The novel peptide ghrelin displays multiple endocrine and non-endocrine actions. Its strong GH-releasing activity in humans has long been recognized. However, in obesity, ghrelin administration induces a blunted GH secretion, enhances glucose and reduces insulin levels. The effects of ghrelin administration have not been investigated in polycystic ovary syndrome (PCOS), which can be associated with obesity, hyperinsulinism, and GH hyposecretion. Leptin is a mediator for energy balance opposed to ghrelin; both of them are supposed to act as regulators of reproductive functions.

KW - Adult

KW - Blood Glucose

KW - Fatty Acids, Nonesterified

KW - Female

KW - Ghrelin

KW - Growth Hormone

KW - Humans

KW - Insulin

KW - Leptin

KW - Obesity

KW - Polycystic Ovary Syndrome

KW - Prolactin

KW - Thyrotropin

KW - Adult

KW - Blood Glucose

KW - Fatty Acids, Nonesterified

KW - Female

KW - Ghrelin

KW - Growth Hormone

KW - Humans

KW - Insulin

KW - Leptin

KW - Obesity

KW - Polycystic Ovary Syndrome

KW - Prolactin

KW - Thyrotropin

UR - http://hdl.handle.net/10807/13193

M3 - Article

SN - 1720-8386

VL - 30

SP - 948

EP - 956

JO - Journal of Endocrinological Investigation

JF - Journal of Endocrinological Investigation

ER -

Effects of ghrelin administration on endocrine and metabolic parameters in obese women with polycystic ovary syndrome

Abstract

Keywords

OSS delle Nazioni Unite

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Fingerprint

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