Effects of ghrelin administration on endocrine and metabolic parameters in obese women with polycystic ovary syndrome

Alessandra Fusco, Antonio Bianchi, Antonio Mancini, Domenico Milardi, Antonella Giampietro, V Cimino, Teresa Porcelli, Daniela Romualdi, Maurizio Guido, Antonio Lanzone, Alfredo Pontecorvi, Laura De Marinis Grasso

Risultato della ricerca: Contributo in rivistaArticolo

26 Citazioni (Scopus)

Abstract

The novel peptide ghrelin displays multiple endocrine and non-endocrine actions. Its strong GH-releasing activity in humans has long been recognized. However, in obesity, ghrelin administration induces a blunted GH secretion, enhances glucose and reduces insulin levels. The effects of ghrelin administration have not been investigated in polycystic ovary syndrome (PCOS), which can be associated with obesity, hyperinsulinism, and GH hyposecretion. Leptin is a mediator for energy balance opposed to ghrelin; both of them are supposed to act as regulators of reproductive functions.
Lingua originaleInglese
pagine (da-a)948-956
Numero di pagine9
RivistaJournal of Endocrinological Investigation
Volume30
Stato di pubblicazionePubblicato - 2007

Keywords

  • Adult
  • Blood Glucose
  • Fatty Acids, Nonesterified
  • Female
  • Ghrelin
  • Growth Hormone
  • Humans
  • Insulin
  • Leptin
  • Obesity
  • Polycystic Ovary Syndrome
  • Prolactin
  • Thyrotropin

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