Effects of ghrelin administration on endocrine and metabolic parameters in obese women with polycystic ovary syndrome

Antonio Mancini, Antonio Lanzone, Alfredo Pontecorvi, Alessandra Fusco, Antonio Bianchi, Domenico Milardi, Antonella Giampietro, Daniela Romualdi, Maurizio Guido, Laura De Marinis Grasso, V Cimino, Teresa Porcelli

Risultato della ricerca: Contributo in rivistaArticolo in rivista

26 Citazioni (Scopus)

Abstract

The novel peptide ghrelin displays multiple endocrine and non-endocrine actions. Its strong GH-releasing activity in humans has long been recognized. However, in obesity, ghrelin administration induces a blunted GH secretion, enhances glucose and reduces insulin levels. The effects of ghrelin administration have not been investigated in polycystic ovary syndrome (PCOS), which can be associated with obesity, hyperinsulinism, and GH hyposecretion. Leptin is a mediator for energy balance opposed to ghrelin; both of them are supposed to act as regulators of reproductive functions.
Lingua originaleEnglish
pagine (da-a)948-956
Numero di pagine9
RivistaJournal of Endocrinological Investigation
Volume30
Stato di pubblicazionePubblicato - 2007

Keywords

  • Adult
  • Blood Glucose
  • Fatty Acids, Nonesterified
  • Female
  • Ghrelin
  • Growth Hormone
  • Humans
  • Insulin
  • Leptin
  • Obesity
  • Polycystic Ovary Syndrome
  • Prolactin
  • Thyrotropin

Fingerprint

Entra nei temi di ricerca di 'Effects of ghrelin administration on endocrine and metabolic parameters in obese women with polycystic ovary syndrome'. Insieme formano una fingerprint unica.

Cita questo