Effects of early dexamethasone therapy on pulmonary fibrogenic mediators and respiratory mechanism in preterm infants

Giovanni Vento, Luca Tortorolo, Piero Giuseppe Matassa, Costantino Romagnoli

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Corticosteroid administration may prevent chronic lung disease in premature newborns, perhaps by modulating the synthesis of various cytokines, including those involved in fibrogenic processes. This study analyses the levels of three fibrogenic cytokines, namely vascular endothelial growth factor, transforming growth factor-beta 1 and basic fibroblast growth factor in tracheobronchial aspirate fluids collected from 20 premature newborns randomly assigned to the early dexamethasone group or to the control group. Furthermore, pulmonary function tests were performed on days 0 and 2 following the start of therapy. The results show that early corticosteroid administration reduces transforming growth factor-beta 1 and basic fibroblast growth factor levels, and abolishes the spontaneous vascular endothelial growth factor increase observed in untreated patients, concomitantly with significant improvement of dynamic lung compliance and shorter duration of the intubation period in the treated group of patients. Significant correlations were observed between the levels of transforming growth factor-beta 1 and vascular endothelial growth factor, indicating that the production of both these cytokines is coordinated. Finally, transforming growth factor-beta 1 ratios (day 2/day 0), representing early variations of the cytokine levels, were significantly different between treated and untreated subjects and correlated with the dynamic lung compliance ratios and the extubation day, suggesting that the downmodulation of some fibrogenic mediators may be involved in the mode of action of dexamethasone.
Lingua originaleEnglish
pagine (da-a)207-214
Numero di pagine8
RivistaEuropean Cytokine Network
Stato di pubblicazionePubblicato - 2002

Keywords

  • dexamethasone
  • preterm infants

Fingerprint

Entra nei temi di ricerca di 'Effects of early dexamethasone therapy on pulmonary fibrogenic mediators and respiratory mechanism in preterm infants'. Insieme formano una fingerprint unica.

Cita questo