Effects of drospirenone-ethinylestradiol and/or metformin on CD4(+)CD28(null) T lymphocytes frequency in women with hyperinsulinemia having polycystic ovary syndrome: a randomized clinical trial.

Francesca Moro, Andrea Morciano, Anna Tropea, Francesca Sagnella, Carola Palla, Elisa Scarinci, Andrea Ciardulli, Daniela Martinez, Alessandra Familiari, Giovanna Liuzzo, Alessandra Tritarelli, Nicola Cosentino, Giampaolo Niccoli, Filippo Crea, Antonio Lanzone, Rosanna Apa

Risultato della ricerca: Contributo in rivistaArticolo in rivista

14 Citazioni (Scopus)

Abstract

OBJECTIVE: To evaluate the long-term effects of drospirenone (DRSP)/ethinylestradiol (EE) alone, metformin alone, and DRSP/EE-metformin on CD4(+)CD28(null) T lymphocytes frequency, a cardiovascular risk marker, in patients with hyperinsulinemic polycystic ovary syndrome (PCOS). DESIGN: Randomized clinical trial. INTERVENTIONS: Ninety three patients with hyperinsulinemic PCOS were age matched and body mass index matched and randomized to receive a 6 months daily treatment with DRSP (3 mg)/EE (0.03 mg), or metformin (1500 mg), or DRSP/EE combined with metformin. MAIN OUTCOME MEASURES: CD4(+)CD28(null) T-cell frequencies. RESULTS: The DRSP/EE and metformin groups did not show any significant change in the CD4(+)CD28(null) frequency compared to the baseline. Interestingly, a statistically significant decrease in CD4(+)CD28(null) frequency occurred after 6 months of DRSP/EE-metformin (median 3-1.5; P < .01). Of note, this statistically significant association was confirmed after adjusting for baseline values in DRSP/EE-metformin group by analysis of covariance (P < .05). CONCLUSIONS: In women with hyperinsulinemic PCOS, combined therapy with DRSP/EE and metformin may reduce cardiovascular risk.
Lingua originaleEnglish
pagine (da-a)1508-1517
Numero di pagine10
RivistaReproductive Sciences
Volume2013
DOI
Stato di pubblicazionePubblicato - 2013

Keywords

  • CD4+CD28null T-lymphocytes
  • drospirenone
  • ethinylestradiol
  • metformin
  • polycystic ovary syndrome

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