Effects of a new combination of plant extracts plus d-mannose for the management of uncomplicated recurrent urinary tract infections

Salvatore Maria Corsello, Carmela Genovese, Carlo Genovese, Sergio Davinelli, Katia Mangano, Gianna Tempera, Daria Nicolosi, Franca Vergalito, Edoardo Tartaglia, Giovanni Scapagnini, Roberto Di Marco

Risultato della ricerca: Contributo in rivistaArticolo in rivista

24 Citazioni (Scopus)

Abstract

Urinary tract infections (UTIs) are an economic burden for public health. The increasing prevalence of resistant bacteria which cause UTIs may be related to the inappropriate prescription of antibiotics. The aim of this preliminary study was to evaluate whether three different combinations of plant extracts plus d-mannose are effective in preventing the recurrence of UTIs. Three groups of patients received three combinations of plant extracts in conjunction with d-mannose. These were: berberine, arbutin and birch (group A); berberine, arbutin, birch and forskolin (group B); and proanthocyanidins (group C). The clinical recurrence of cystitis at the end of treatment and during follow-up was determined by comparison with baseline measurements using the microbiological assessment of urine samples, vaginal swabs and vaginal smear slides. Patients in groups A and B had a lower incidence of episodes of recurrent cystitis during treatment and follow-up, samples with a significantly lower median bacterial load and a reduction of the grade of lactobacillary flora compared to patients in group C.
Lingua originaleEnglish
pagine (da-a)107-114
Numero di pagine8
RivistaJournal of Chemotherapy
Volume30
DOI
Stato di pubblicazionePubblicato - 2018

Keywords

  • Cystitis
  • Urinary Tract Infections
  • Plant extracts
  • Prevention
  • Recurrent urinary tract infections
  • Adult
  • Anti-Bacterial Agents
  • Drug Combinations
  • Escherichia coli
  • Escherichia coli Infections
  • Female
  • Humans
  • Mannose
  • Plant Extracts
  • Recurrence
  • d-mannose

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