Effectiveness of Ketorolac Tromethamine in Prevention of Severe Retinopathy of Prematurity.

Patrizia Papacci, Fernando Molle, Domenico Lepore, Carmen Giannantonio, Velia Purcaro, Francesco Cota, Antonio Baldascino, Costantino Romagnoli, 33186, DI MEDICINA E CHIRURGIA "A.GEMELLI" FACOLTA', ROMA - Dipartimento Testa-collo e organi di senso, 33190, DI MEDICINA E CHIRURGIA "A.GEMELLI" FACOLTA', ROMA - Dipartimento di Scienze della vita e sanità pubblica, DI MEDICINA E CHIRURGIA "A.GEMELLI" FACOLTA', Ghennet Tesfagabir

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

BACKGROUND:This study assessed the effectiveness of the use of ketorolac tromethamine to reduce retinopathy of prematurity (ROP) incidence and its progression to more severe forms. METHODS:Forty-seven preterm newborn infants with a birth weight (BW) of 1,000 grams or less and/or a gestational age (GA) of 29 weeks or less were enrolled in the study when avascular retina zone I or ROP any stage were diagnosed at screening. Studied infants were randomized to receive ketorolac tromethamine ophthalmic solution in one eye and a drop of placebo in the other eye, until ROP requiring treatment or full retinal vascularization was diagnosed. RESULTS:Only 2 newborn infants did not develop ROP. Among 45 newborn infants who developed ROP, 6 showed different ROP staging between the two eyes, 4 of which had a better outcome in the eye receiving ketorolac tromethamine. The differences between ROP stagings were not significant even when analyzed by GA and BW subgroups. No significant treatment-related side effects occurred. CONCLUSION:This report suggests that ketorolac tromethamine ophthalmic solution cannot reduce the risk of developing severe ROP in preterm infants.
Lingua originaleEnglish
pagine (da-a)1-5
Numero di pagine5
RivistaJOURNAL OF PEDIATRIC OPHTHALMOLOGY & STRABISMUS
Stato di pubblicazionePubblicato - 2010

Keywords

  • Ketorolac Tromethamine

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