Effectiveness of 7-valent pneumococcal conjugate vaccine: A meta-analysis of post-marketing studies

Maria Lucia Specchia, Gualtiero Ricciardi, Chiara De Waure, Silvio Capizzi, Admir Malaj, M Aljicevic, M Dujovic

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

AIM: To investigate the 7-valent pneumococcalconjugate vaccine (PCV7) effectiveness. METHODS: A systematic literature review of studies which evaluated the effectiveness of PCV7 vaccine was performed searching the keyword “heptavalent pneumococcal conjugate vaccine” in PubMed and Scopus until March 16, 2013. The selection of potential eligible articles was done by two researchers independently on the basis of abstract and title and only post-marketing studies were included in the systematic review. Data extraction was carried out by two researchers with respect to invasive pneumococcal diseases due to both all and vaccine serotypes in pre-vaccine and postvaccine periods in children less than 5 years. Results of studies which were considered suitable for meta-analysis were combined by means of relative risk (RR) with 95%CI. Vaccine effectiveness was calculated as (1-RR) × 100. Heterogeneity was assessed by I 2 and a random effects model was used to combine data in the case of heterogeneity. RevMan 5 was used to pool data. RESULTS: On the whole, 757 eligible papers were identified from the literature search in PubMed and Scopus. Of them, 62 were finally considered in the systematic review and 38 were included in the meta-analysis. In all post-marketing studies included in the systematic review the incidence of invasive pneumococcal diseases due to vaccine serotypes declined significantly with the exception of few studies showing stability or a slight, but not significant, increase. Furthermore most of studies highlighted also a reduction in the incidence of invasive pneumococcal diseases due to all serotypes. With regards to meta-analysis, a random effects model was used to combine data because of the high heterogeneity. Data combination showed that the effectiveness of PCV7 in reducing invasive pneumococcal diseases due to vaccine serotypes and to all serotypes was 84% (95%CI: 74%-90%) and 53% (95%CI: 46%-59%) respectively. These results are confirmatory with respect to the efficacy of PCV7 against invasive pneumococcal diseases due to vaccine serotypes. CONCLUSION: PCV7 implementation determines a significant decrease of invasive pneumococcal diseases.
Lingua originaleEnglish
pagine (da-a)151-162
Numero di pagine12
RivistaWORLD JOURNAL OF META-ANALYSIS
Stato di pubblicazionePubblicato - 2015

Keywords

  • Effectiveness
  • pneumococcal vaccine

Fingerprint Entra nei temi di ricerca di 'Effectiveness of 7-valent pneumococcal conjugate vaccine: A meta-analysis of post-marketing studies'. Insieme formano una fingerprint unica.

Cita questo