Effectiveness and side effects of two different doses of caffeine in preventing apnea in premature infants

Costantino Romagnoli; Maria Pia De Carolis; Umberto Muzii; Enrico Zecca; Giuseppe Gio Batta Tortorolo; Marcello Chiarotti; Nadia De Giovanni; Aldo Carnevale

Effectiveness and side effects of two different doses of caffeine in preventing apnea in premature infants

Costantino Romagnoli, Maria Pia De Carolis, Umberto Muzii, Enrico Zecca, Giuseppe Gio Batta Tortorolo, Marcello Chiarotti, Nadia De Giovanni, Aldo Carnevale

Università Cattolica del Sacro Cuore

Risultato della ricerca: Contributo in rivista › Articolo in rivista

Abstract

The effectiveness of caffeine citrate in preventing idiopathic apnea in premature infants was evaluated. Thirty-seven preterm infants born before the 32nd week of gestation were studied. After an intravenous loading dose of 10 mg/kg of caffeine citrate, two different oral maintenance regimens were followed: 5 mg/kg in Group I and 2.5 mg/kg in Group II. A significant decrease in the number of apneic spells occurred in both treated groups as compared with a control group. In Group II, the frequency of side effects such as tachycardia and gastrointestinal intolerance was significantly lower than in Group I. Group II theophylline plasma levels were significantly lower than those of Group I. The lower Group II theophylline levels presumably explain the reduced frequency of side effects.

Lingua originale	English
pagine (da-a)	14-19
Numero di pagine	6
Rivista	Therapeutic Drug Monitoring
Stato di pubblicazione	Pubblicato - 1992

Keywords

apnea
caffeine

Altri file e collegamenti

Link a IRIS PubliCatt

Cita questo

@article{b245e5af02f64a90b8bd112a12f486b0,

title = "Effectiveness and side effects of two different doses of caffeine in preventing apnea in premature infants",

abstract = "The effectiveness of caffeine citrate in preventing idiopathic apnea in premature infants was evaluated. Thirty-seven preterm infants born before the 32nd week of gestation were studied. After an intravenous loading dose of 10 mg/kg of caffeine citrate, two different oral maintenance regimens were followed: 5 mg/kg in Group I and 2.5 mg/kg in Group II. A significant decrease in the number of apneic spells occurred in both treated groups as compared with a control group. In Group II, the frequency of side effects such as tachycardia and gastrointestinal intolerance was significantly lower than in Group I. Group II theophylline plasma levels were significantly lower than those of Group I. The lower Group II theophylline levels presumably explain the reduced frequency of side effects.",

keywords = "apnea, caffeine, apnea, caffeine",

author = "Costantino Romagnoli and {De Carolis}, {Maria Pia} and Umberto Muzii and Enrico Zecca and Tortorolo, {Giuseppe Gio Batta} and Marcello Chiarotti and {De Giovanni}, Nadia and Aldo Carnevale",

year = "1992",

language = "English",

pages = "14--19",

journal = "Therapeutic Drug Monitoring",

issn = "0163-4356",

publisher = "primo editore, Raven press New York Editore attuale: Lippincott, Williams & Wilkins:530 Walnut Street:Philadelphia, PA 19106:(800)638-3030, (301)223-2300, EMAIL: [email protected], INTERNET: http://www.lww.com, Fax: (301)223-2320, (301)223-2320",

}

TY - JOUR

T1 - Effectiveness and side effects of two different doses of caffeine in preventing apnea in premature infants

AU - Romagnoli, Costantino

AU - De Carolis, Maria Pia

AU - Muzii, Umberto

AU - Zecca, Enrico

AU - Tortorolo, Giuseppe Gio Batta

AU - Chiarotti, Marcello

AU - De Giovanni, Nadia

AU - Carnevale, Aldo

PY - 1992

Y1 - 1992

N2 - The effectiveness of caffeine citrate in preventing idiopathic apnea in premature infants was evaluated. Thirty-seven preterm infants born before the 32nd week of gestation were studied. After an intravenous loading dose of 10 mg/kg of caffeine citrate, two different oral maintenance regimens were followed: 5 mg/kg in Group I and 2.5 mg/kg in Group II. A significant decrease in the number of apneic spells occurred in both treated groups as compared with a control group. In Group II, the frequency of side effects such as tachycardia and gastrointestinal intolerance was significantly lower than in Group I. Group II theophylline plasma levels were significantly lower than those of Group I. The lower Group II theophylline levels presumably explain the reduced frequency of side effects.

AB - The effectiveness of caffeine citrate in preventing idiopathic apnea in premature infants was evaluated. Thirty-seven preterm infants born before the 32nd week of gestation were studied. After an intravenous loading dose of 10 mg/kg of caffeine citrate, two different oral maintenance regimens were followed: 5 mg/kg in Group I and 2.5 mg/kg in Group II. A significant decrease in the number of apneic spells occurred in both treated groups as compared with a control group. In Group II, the frequency of side effects such as tachycardia and gastrointestinal intolerance was significantly lower than in Group I. Group II theophylline plasma levels were significantly lower than those of Group I. The lower Group II theophylline levels presumably explain the reduced frequency of side effects.

KW - apnea

KW - caffeine

KW - apnea

KW - caffeine

UR - http://hdl.handle.net/10807/24239

M3 - Article

SN - 0163-4356

SP - 14

EP - 19

JO - Therapeutic Drug Monitoring

JF - Therapeutic Drug Monitoring

ER -

Effectiveness and side effects of two different doses of caffeine in preventing apnea in premature infants

Abstract

Keywords

Altri file e collegamenti

Fingerprint

Cita questo