Effect of vagal nerve stimulation on systemic inflammation and cardiac autonomic function in patients with refractory epilepsy

Lucy Barone; Gabriella Colicchio; Domenico Policicchio; Francesca Di Clemente; Antonio Di Monaco; Mario Meglio; Gaetano Antonio Lanza; Filippo Crea

doi:10.1159/000127360

Effect of vagal nerve stimulation on systemic inflammation and cardiac autonomic function in patients with refractory epilepsy

Lucy Barone, Gabriella Colicchio, Domenico Policicchio, Francesca Di Clemente, Antonio Di Monaco, Mario Meglio, Gaetano Antonio Lanza, Filippo Crea

Risultato della ricerca: Contributo in rivista › Articolo in rivista

26 Citazioni (Scopus)

Abstract

Recent data suggest that vagus nerve stimulation (VNS) can inhibit cytokine release by inflammatory cells. Accordingly, an association between impaired cardiac parasympathetic function, as assessed by heart rate variability (HRV), and increased markers of inflammation has recently been reported. In this study we assessed the effect of direct left VNS on inflammatory markers and HRV in patients with refractory epilepsy.

Lingua originale	English
pagine (da-a)	331-336
Numero di pagine	6
Rivista	NeuroImmunoModulation
Volume	14
DOI	https://doi.org/10.1159/000127360
Stato di pubblicazione	Pubblicato - 2007

Keywords

Adolescent
Adult
Aged
Autonomic Nervous System
C-Reactive Protein
Child
Electric Stimulation Therapy
Electrocardiography, Ambulatory
Epilepsy
Female
Heart
Heart Rate
Humans
Inflammation
Interleukin-6
Male
Neuroimmunomodulation
Tumor Necrosis Factor-alpha
Vagus Nerve

Accesso al documento

10.1159/000127360

Altri file e collegamenti

Link a IRIS PubliCatt

Cita questo

@article{ae5f83af3b6f42309871063ba6c0b6ac,

title = "Effect of vagal nerve stimulation on systemic inflammation and cardiac autonomic function in patients with refractory epilepsy",

abstract = "Recent data suggest that vagus nerve stimulation (VNS) can inhibit cytokine release by inflammatory cells. Accordingly, an association between impaired cardiac parasympathetic function, as assessed by heart rate variability (HRV), and increased markers of inflammation has recently been reported. In this study we assessed the effect of direct left VNS on inflammatory markers and HRV in patients with refractory epilepsy.",

keywords = "Adolescent, Adult, Aged, Autonomic Nervous System, C-Reactive Protein, Child, Electric Stimulation Therapy, Electrocardiography, Ambulatory, Epilepsy, Female, Heart, Heart Rate, Humans, Inflammation, Interleukin-6, Male, Neuroimmunomodulation, Tumor Necrosis Factor-alpha, Vagus Nerve, Adolescent, Adult, Aged, Autonomic Nervous System, C-Reactive Protein, Child, Electric Stimulation Therapy, Electrocardiography, Ambulatory, Epilepsy, Female, Heart, Heart Rate, Humans, Inflammation, Interleukin-6, Male, Neuroimmunomodulation, Tumor Necrosis Factor-alpha, Vagus Nerve",

author = "Lucy Barone and Gabriella Colicchio and Domenico Policicchio and {Di Clemente}, Francesca and {Di Monaco}, Antonio and Mario Meglio and Lanza, {Gaetano Antonio} and Filippo Crea",

year = "2007",

doi = "10.1159/000127360",

language = "English",

volume = "14",

pages = "331--336",

journal = "NeuroImmunoModulation",

issn = "1021-7401",

publisher = "S. Karger AG",

}

TY - JOUR

T1 - Effect of vagal nerve stimulation on systemic inflammation and cardiac autonomic function in patients with refractory epilepsy

AU - Barone, Lucy

AU - Colicchio, Gabriella

AU - Policicchio, Domenico

AU - Di Clemente, Francesca

AU - Di Monaco, Antonio

AU - Meglio, Mario

AU - Lanza, Gaetano Antonio

AU - Crea, Filippo

PY - 2007

Y1 - 2007

N2 - Recent data suggest that vagus nerve stimulation (VNS) can inhibit cytokine release by inflammatory cells. Accordingly, an association between impaired cardiac parasympathetic function, as assessed by heart rate variability (HRV), and increased markers of inflammation has recently been reported. In this study we assessed the effect of direct left VNS on inflammatory markers and HRV in patients with refractory epilepsy.

AB - Recent data suggest that vagus nerve stimulation (VNS) can inhibit cytokine release by inflammatory cells. Accordingly, an association between impaired cardiac parasympathetic function, as assessed by heart rate variability (HRV), and increased markers of inflammation has recently been reported. In this study we assessed the effect of direct left VNS on inflammatory markers and HRV in patients with refractory epilepsy.

KW - Adolescent

KW - Adult

KW - Aged

KW - Autonomic Nervous System

KW - C-Reactive Protein

KW - Child

KW - Electric Stimulation Therapy

KW - Electrocardiography, Ambulatory

KW - Epilepsy

KW - Female

KW - Heart

KW - Heart Rate

KW - Humans

KW - Inflammation

KW - Interleukin-6

KW - Male

KW - Neuroimmunomodulation

KW - Tumor Necrosis Factor-alpha

KW - Vagus Nerve

KW - Adolescent

KW - Adult

KW - Aged

KW - Autonomic Nervous System

KW - C-Reactive Protein

KW - Child

KW - Electric Stimulation Therapy

KW - Electrocardiography, Ambulatory

KW - Epilepsy

KW - Female

KW - Heart

KW - Heart Rate

KW - Humans

KW - Inflammation

KW - Interleukin-6

KW - Male

KW - Neuroimmunomodulation

KW - Tumor Necrosis Factor-alpha

KW - Vagus Nerve

UR - http://hdl.handle.net/10807/34000

U2 - 10.1159/000127360

DO - 10.1159/000127360

M3 - Article

SN - 1021-7401

VL - 14

SP - 331

EP - 336

JO - NeuroImmunoModulation

JF - NeuroImmunoModulation

ER -

Effect of vagal nerve stimulation on systemic inflammation and cardiac autonomic function in patients with refractory epilepsy

Abstract

Keywords

Accesso al documento

Altri file e collegamenti

Fingerprint

Cita questo