Effect of oral sebacic Acid on postprandial glycemia, insulinemia, and glucose rate of appearance in type 2 diabetes

Amerigo Iaconelli; Amalia Gastaldelli; Chiara Chiellini; Donatella Gniuli; Angela Maria Rita Favuzzi; Christophe Binnert; Katherine Macé; Geltrude Mingrone

doi:10.2337/dc10-0663

Effect of oral sebacic Acid on postprandial glycemia, insulinemia, and glucose rate of appearance in type 2 diabetes

Amerigo Iaconelli
, Amalia Gastaldelli
, Chiara Chiellini
, Donatella Gniuli
, Angela Maria Rita Favuzzi
, Christophe Binnert
, Katherine Macé
, Geltrude Mingrone

Risultato della ricerca: Contributo in rivista › Articolo

10 Citazioni (Scopus)

Abstract

Dicarboxylic acids are natural products with the potential of being an alternate dietary source of energy. We aimed to evaluate the effect of sebacic acid (a 10-carbon dicarboxylic acid; C10) ingestion on postprandial glycemia and glucose rate of appearance (Ra) in healthy and type 2 diabetic subjects. Furthermore, the effect of C10 on insulin-mediated glucose uptake and on GLUT4 expression was assessed in L6 muscle cells in vitro.

Lingua originale	Inglese
pagine (da-a)	2327-2332
Numero di pagine	6
Rivista	Diabetes Care
Volume	33
DOI	https://doi.org/10.2337/dc10-0663
Stato di pubblicazione	Pubblicato - 2010

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Keywords

Absorptiometry, Photon
Animals
Biological Transport
Blood Glucose
Blotting, Western
Body Composition
C-Peptide
Cell Line
Decanoic Acids
Diabetes Mellitus, Type 2
Dicarboxylic Acids
Female
Gas Chromatography-Mass Spectrometry
Humans
Immunoprecipitation
Insulin
Male
Middle Aged
Postprandial Period
Rats

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title = "Effect of oral sebacic Acid on postprandial glycemia, insulinemia, and glucose rate of appearance in type 2 diabetes",

abstract = "Dicarboxylic acids are natural products with the potential of being an alternate dietary source of energy. We aimed to evaluate the effect of sebacic acid (a 10-carbon dicarboxylic acid; C10) ingestion on postprandial glycemia and glucose rate of appearance (Ra) in healthy and type 2 diabetic subjects. Furthermore, the effect of C10 on insulin-mediated glucose uptake and on GLUT4 expression was assessed in L6 muscle cells in vitro.",

keywords = "Absorptiometry, Photon, Animals, Biological Transport, Blood Glucose, Blotting, Western, Body Composition, C-Peptide, Cell Line, Decanoic Acids, Diabetes Mellitus, Type 2, Dicarboxylic Acids, Female, Gas Chromatography-Mass Spectrometry, Humans, Immunoprecipitation, Insulin, Male, Middle Aged, Postprandial Period, Rats, Absorptiometry, Photon, Animals, Biological Transport, Blood Glucose, Blotting, Western, Body Composition, C-Peptide, Cell Line, Decanoic Acids, Diabetes Mellitus, Type 2, Dicarboxylic Acids, Female, Gas Chromatography-Mass Spectrometry, Humans, Immunoprecipitation, Insulin, Male, Middle Aged, Postprandial Period, Rats",

author = "Amerigo Iaconelli and Amalia Gastaldelli and Chiara Chiellini and Donatella Gniuli and Favuzzi, \{Angela Maria Rita\} and Christophe Binnert and Katherine Mac{\'e} and Geltrude Mingrone",

year = "2010",

doi = "10.2337/dc10-0663",

language = "English",

volume = "33",

pages = "2327--2332",

journal = "Diabetes Care",

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publisher = "American Diabetes Association Inc.",

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T1 - Effect of oral sebacic Acid on postprandial glycemia, insulinemia, and glucose rate of appearance in type 2 diabetes

AU - Iaconelli, Amerigo

AU - Gastaldelli, Amalia

AU - Chiellini, Chiara

AU - Gniuli, Donatella

AU - Favuzzi, Angela Maria Rita

AU - Binnert, Christophe

AU - Macé, Katherine

AU - Mingrone, Geltrude

PY - 2010

Y1 - 2010

N2 - Dicarboxylic acids are natural products with the potential of being an alternate dietary source of energy. We aimed to evaluate the effect of sebacic acid (a 10-carbon dicarboxylic acid; C10) ingestion on postprandial glycemia and glucose rate of appearance (Ra) in healthy and type 2 diabetic subjects. Furthermore, the effect of C10 on insulin-mediated glucose uptake and on GLUT4 expression was assessed in L6 muscle cells in vitro.

AB - Dicarboxylic acids are natural products with the potential of being an alternate dietary source of energy. We aimed to evaluate the effect of sebacic acid (a 10-carbon dicarboxylic acid; C10) ingestion on postprandial glycemia and glucose rate of appearance (Ra) in healthy and type 2 diabetic subjects. Furthermore, the effect of C10 on insulin-mediated glucose uptake and on GLUT4 expression was assessed in L6 muscle cells in vitro.

KW - Absorptiometry, Photon

KW - Animals

KW - Biological Transport

KW - Blood Glucose

KW - Blotting, Western

KW - Body Composition

KW - C-Peptide

KW - Cell Line

KW - Decanoic Acids

KW - Diabetes Mellitus, Type 2

KW - Dicarboxylic Acids

KW - Female

KW - Gas Chromatography-Mass Spectrometry

KW - Humans

KW - Immunoprecipitation

KW - Insulin

KW - Male

KW - Middle Aged

KW - Postprandial Period

KW - Rats

KW - Absorptiometry, Photon

KW - Animals

KW - Biological Transport

KW - Blood Glucose

KW - Blotting, Western

KW - Body Composition

KW - C-Peptide

KW - Cell Line

KW - Decanoic Acids

KW - Diabetes Mellitus, Type 2

KW - Dicarboxylic Acids

KW - Female

KW - Gas Chromatography-Mass Spectrometry

KW - Humans

KW - Immunoprecipitation

KW - Insulin

KW - Male

KW - Middle Aged

KW - Postprandial Period

KW - Rats

UR - http://hdl.handle.net/10807/7142

U2 - 10.2337/dc10-0663

DO - 10.2337/dc10-0663

M3 - Article

SN - 1935-5548

VL - 33

SP - 2327

EP - 2332

JO - Diabetes Care

JF - Diabetes Care

ER -

Effect of oral sebacic Acid on postprandial glycemia, insulinemia, and glucose rate of appearance in type 2 diabetes

Abstract

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Keywords

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