Effect of natural beta-interferon on estrogen receptor mRNA of breast cancer cells

Cristiana Angelucci, Fortunata Iacopino, Gigliola Sica, Gina Lama

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9 Citazioni (Scopus)

Abstract

We have demonstrated that natural beta-interferon (beta-IFN) enhances estrogen receptor (ER) mRNA of a human breast cancer cell line, CG-5. Cells were sensitive to the effect of beta-IFN at concentrations ranging from 10 to 100 IU/ml. The increase of ER mRNA was seen after 48 hr of treatment in at least three separate experiments. Our results are in agreement with the previously observed enhancement of receptor protein. In addition, they suggest that the IFN-induced promotion of the antiproliferative activity of drugs which act via ER may be due, in part, to increased receptor synthesis.
Lingua originaleEnglish
pagine (da-a)2061-2064
Numero di pagine4
RivistaAnticancer Research
Volume12
Stato di pubblicazionePubblicato - 1992

Keywords

  • Interferon, ER mRNA, breast cancer cells

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