Effect of natural beta-interferon on estrogen receptor mRNA of breast cancer cells

Gigliola Sica; Cristiana Angelucci; Fortunata Iacopino; Gina Lama; G. Robustelli Della Cuna; O. Serlupi-Crescenzi; S. Donini

Effect of natural beta-interferon on estrogen receptor mRNA of breast cancer cells

Gigliola Sica, Cristiana Angelucci, Fortunata Iacopino, Gina Lama, G. Robustelli Della Cuna, O. Serlupi-Crescenzi, S. Donini

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

9 Citazioni (Scopus)

Abstract

We have demonstrated that natural beta-interferon (beta-IFN) enhances estrogen receptor (ER) mRNA of a human breast cancer cell line, CG-5. Cells were sensitive to the effect of beta-IFN at concentrations ranging from 10 to 100 IU/ml. The increase of ER mRNA was seen after 48 hr of treatment in at least three separate experiments. Our results are in agreement with the previously observed enhancement of receptor protein. In addition, they suggest that the IFN-induced promotion of the antiproliferative activity of drugs which act via ER may be due, in part, to increased receptor synthesis.

Lingua originale	English
pagine (da-a)	2061-2064
Numero di pagine	4
Rivista	Anticancer Research
Volume	12
Stato di pubblicazione	Pubblicato - 1992

Keywords

Interferon, ER mRNA, breast cancer cells

OSS delle Nazioni Unite

Questo processo contribuisce al raggiungimento dei seguenti obiettivi di sviluppo sostenibile

Altri file e collegamenti

Link a IRIS PubliCatt

Cita questo

@article{a81b22156d0048cc95f5aa7bf28fe12c,

title = "Effect of natural beta-interferon on estrogen receptor mRNA of breast cancer cells",

abstract = "We have demonstrated that natural beta-interferon (beta-IFN) enhances estrogen receptor (ER) mRNA of a human breast cancer cell line, CG-5. Cells were sensitive to the effect of beta-IFN at concentrations ranging from 10 to 100 IU/ml. The increase of ER mRNA was seen after 48 hr of treatment in at least three separate experiments. Our results are in agreement with the previously observed enhancement of receptor protein. In addition, they suggest that the IFN-induced promotion of the antiproliferative activity of drugs which act via ER may be due, in part, to increased receptor synthesis.",

keywords = "Interferon, ER mRNA, breast cancer cells, Interferon, ER mRNA, breast cancer cells",

author = "Gigliola Sica and Cristiana Angelucci and Fortunata Iacopino and Gina Lama and {Robustelli Della Cuna}, G. and O. Serlupi-Crescenzi and S. Donini",

year = "1992",

language = "English",

volume = "12",

pages = "2061--2064",

journal = "Anticancer Research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research:John G Delinassios, 1st Km Kapandritiou-Kalamou Road, Kapandriti Attiki 19014 Greece:011 30 2 2950 53389, 011 30 2950 52945, EMAIL: journals@iiar-anticancer.org, INTERNET: http://www.iiar-anticancer.org, Fax: 011 30 2 2950 53389, 011 30 2 2950 52945",

}

TY - JOUR

T1 - Effect of natural beta-interferon on estrogen receptor mRNA of breast cancer cells

AU - Sica, Gigliola

AU - Angelucci, Cristiana

AU - Iacopino, Fortunata

AU - Lama, Gina

AU - Robustelli Della Cuna, G.

AU - Serlupi-Crescenzi, O.

AU - Donini, S.

PY - 1992

Y1 - 1992

N2 - We have demonstrated that natural beta-interferon (beta-IFN) enhances estrogen receptor (ER) mRNA of a human breast cancer cell line, CG-5. Cells were sensitive to the effect of beta-IFN at concentrations ranging from 10 to 100 IU/ml. The increase of ER mRNA was seen after 48 hr of treatment in at least three separate experiments. Our results are in agreement with the previously observed enhancement of receptor protein. In addition, they suggest that the IFN-induced promotion of the antiproliferative activity of drugs which act via ER may be due, in part, to increased receptor synthesis.

AB - We have demonstrated that natural beta-interferon (beta-IFN) enhances estrogen receptor (ER) mRNA of a human breast cancer cell line, CG-5. Cells were sensitive to the effect of beta-IFN at concentrations ranging from 10 to 100 IU/ml. The increase of ER mRNA was seen after 48 hr of treatment in at least three separate experiments. Our results are in agreement with the previously observed enhancement of receptor protein. In addition, they suggest that the IFN-induced promotion of the antiproliferative activity of drugs which act via ER may be due, in part, to increased receptor synthesis.

KW - Interferon, ER mRNA, breast cancer cells

UR - http://hdl.handle.net/10807/160828

M3 - Article

SN - 0250-7005

VL - 12

SP - 2061

EP - 2064

JO - Anticancer Research

JF - Anticancer Research

ER -

Effect of natural beta-interferon on estrogen receptor mRNA of breast cancer cells

Abstract

Keywords

OSS delle Nazioni Unite

Altri file e collegamenti

Fingerprint

Cita questo