TY - JOUR
T1 - Effect of magnesium valproate on amygdala-kindled seizures in the rat: Comparison with sodium valproate
AU - Pallini, Roberto
AU - Palestini, M.
AU - Lauretti, Liverana
AU - Rossi, G. F.
PY - 1989
Y1 - 1989
N2 - The anticonvulsant activity of a salt of valproic acid (VA), magnesium valproate (MgV), was assessed against amygdala-kindled seizures in rats. The anti-epileptic power of MgV was compared with that of sodium valproate (NaV). Kindling was obtained by delivering daily to one of the amygdalae a 2 s train of monophasic square-wave pulses (1 ms, 60 c.p.s., 100-130 μA) via chronically implanted electrodes. Magnesium valproate and NaV were tested once kindling was stabilized and the post-kindling threshold for generalized convulsions was determined. The drugs were administered intraperitoneally in doses ranging from 25 to 200 mg/kg. The injection/test interval was 30 min. Each animal received a single dose every 24 h. Magnesium valproate exhibited an anticonvulsant activity qualitatively and quantitatively similar to that of NaV. Statistically significant differences were not found between the two drugs with respect to the reduction of seizure severity and afterdischarge (AD) duration. The calculated ED50's were 94.58 and 97.41 mg/kg for suppression of generalized seizures, 176,96 and 129,26 mg/kg for the suppression of partial seizures, 275.96 and 224.13 mg/kg for the suppression of the local AD in the MgV and NaV treated groups, respectively.
AB - The anticonvulsant activity of a salt of valproic acid (VA), magnesium valproate (MgV), was assessed against amygdala-kindled seizures in rats. The anti-epileptic power of MgV was compared with that of sodium valproate (NaV). Kindling was obtained by delivering daily to one of the amygdalae a 2 s train of monophasic square-wave pulses (1 ms, 60 c.p.s., 100-130 μA) via chronically implanted electrodes. Magnesium valproate and NaV were tested once kindling was stabilized and the post-kindling threshold for generalized convulsions was determined. The drugs were administered intraperitoneally in doses ranging from 25 to 200 mg/kg. The injection/test interval was 30 min. Each animal received a single dose every 24 h. Magnesium valproate exhibited an anticonvulsant activity qualitatively and quantitatively similar to that of NaV. Statistically significant differences were not found between the two drugs with respect to the reduction of seizure severity and afterdischarge (AD) duration. The calculated ED50's were 94.58 and 97.41 mg/kg for suppression of generalized seizures, 176,96 and 129,26 mg/kg for the suppression of partial seizures, 275.96 and 224.13 mg/kg for the suppression of the local AD in the MgV and NaV treated groups, respectively.
KW - kindling, seizures, valproate
KW - kindling, seizures, valproate
UR - http://hdl.handle.net/10807/162976
U2 - 10.1080/01616412.1989.11739855
DO - 10.1080/01616412.1989.11739855
M3 - Article
SN - 0161-6412
VL - 11
SP - 17
EP - 23
JO - Neurological Research
JF - Neurological Research
ER -