Effect of gonadotrophin-releasing hormone and related analogue on human luteal cell function in vitro

Antonio Lanzone, V. Panetta, Nicoletta Di Simone, E. Arno', A. M. Fulghesu, Alessandro Caruso, Salvatore Mancuso

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

18 Citazioni (Scopus)

Abstract

The possible direct effect of gonadotrophin-releasing hormone (GnRH) and GnRH agonist (GnRH-A; buserelin) on basal and human chorionic gonadotrophin (HCG)-stimulated progesterone (P) and cyclic AMP (cAMP) production by cultured human luteal cells was examined. Luteal cells from the early or mid-luteal phase were incubated in long-term cultures. They responded to HCG stimulation with a 2- to 3-fold increase in P production and a 2-fold increase in cAMP production. The addition of GnRH (10(-7) and 10(-5) M) or GnRH-A (10(-7) and 10(-5) M) to the medium had no effect on either basal or HCG-stimulated secretion. These results indicate that both GnRH and GnRH-A have no direct effect on human luteal steroidogenesis in vitro
Lingua originaleEnglish
pagine (da-a)906-909
Numero di pagine4
RivistaHuman Reproduction
DOI
Stato di pubblicazionePubblicato - 1989

Keywords

  • gonadotrophin-releasing hormone

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