Effect of FK 506 chronic administration on bromosulphthalein hepatic excretion in rats

H Farghali; M Sakr; Antonio Gasbarrini; R Venkataramanan; J Gavaler; Te Starzl; Dh Van Thiel

Effect of FK 506 chronic administration on bromosulphthalein hepatic excretion in rats

H Farghali, M Sakr, Antonio Gasbarrini, R Venkataramanan, J Gavaler, Te Starzl, Dh Van Thiel

Risultato della ricerca: Contributo in rivista › Articolo in rivista

Abstract

There are several reports dealing with the hepatic effect of FK 506,1–4 some of which are beneficial while others are adverse. Because the liver is a major target organ that is often the site of drug toxicity, studies directed at determining whether FK 506 affects specific hepatic function and/or its histologic appearance are important. Therefore, the present study was undertaken to examine bromosulphthalein (BSP) elimination kinetics in rats as a sensitive index of hepatic excretory function under the influence of FK 506 in the rat.

Lingua originale	English
pagine (da-a)	2802-2804
Numero di pagine	3
Rivista	Transplantation Proceedings
Volume	23
Stato di pubblicazione	Pubblicato - 1991

Keywords

Administration, Oral
Animals
Dose-Response Relationship, Drug
Kinetics
Liver
Male
Rats
Rats, Inbred Strains
Sulfobromophthalein
Tacrolimus
Time Factors

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title = "Effect of FK 506 chronic administration on bromosulphthalein hepatic excretion in rats",

abstract = "There are several reports dealing with the hepatic effect of FK 506,1–4 some of which are beneficial while others are adverse. Because the liver is a major target organ that is often the site of drug toxicity, studies directed at determining whether FK 506 affects specific hepatic function and/or its histologic appearance are important. Therefore, the present study was undertaken to examine bromosulphthalein (BSP) elimination kinetics in rats as a sensitive index of hepatic excretory function under the influence of FK 506 in the rat.",

keywords = "Administration, Oral, Animals, Dose-Response Relationship, Drug, Kinetics, Liver, Male, Rats, Rats, Inbred Strains, Sulfobromophthalein, Tacrolimus, Time Factors, Administration, Oral, Animals, Dose-Response Relationship, Drug, Kinetics, Liver, Male, Rats, Rats, Inbred Strains, Sulfobromophthalein, Tacrolimus, Time Factors",

author = "H Farghali and M Sakr and Antonio Gasbarrini and R Venkataramanan and J Gavaler and Te Starzl and {Van Thiel}, Dh",

year = "1991",

language = "English",

volume = "23",

pages = "2802--2804",

journal = "Transplantation Proceedings",

issn = "0041-1345",

publisher = "Elsevier Science Incorporated / NY Journals:Madison Square Station, PO Box 882:New York, NY 10159:(212)633-3730, EMAIL: [email protected], INTERNET: http://www.elsevier.com, Fax: (212)633-3680",

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TY - JOUR

T1 - Effect of FK 506 chronic administration on bromosulphthalein hepatic excretion in rats

AU - Farghali, H

AU - Sakr, M

AU - Gasbarrini, Antonio

AU - Venkataramanan, R

AU - Gavaler, J

AU - Starzl, Te

AU - Van Thiel, Dh

PY - 1991

Y1 - 1991

N2 - There are several reports dealing with the hepatic effect of FK 506,1–4 some of which are beneficial while others are adverse. Because the liver is a major target organ that is often the site of drug toxicity, studies directed at determining whether FK 506 affects specific hepatic function and/or its histologic appearance are important. Therefore, the present study was undertaken to examine bromosulphthalein (BSP) elimination kinetics in rats as a sensitive index of hepatic excretory function under the influence of FK 506 in the rat.

AB - There are several reports dealing with the hepatic effect of FK 506,1–4 some of which are beneficial while others are adverse. Because the liver is a major target organ that is often the site of drug toxicity, studies directed at determining whether FK 506 affects specific hepatic function and/or its histologic appearance are important. Therefore, the present study was undertaken to examine bromosulphthalein (BSP) elimination kinetics in rats as a sensitive index of hepatic excretory function under the influence of FK 506 in the rat.

KW - Administration, Oral

KW - Animals

KW - Dose-Response Relationship, Drug

KW - Kinetics

KW - Liver

KW - Male

KW - Rats

KW - Rats, Inbred Strains

KW - Sulfobromophthalein

KW - Tacrolimus

KW - Time Factors

KW - Administration, Oral

KW - Animals

KW - Dose-Response Relationship, Drug

KW - Kinetics

KW - Liver

KW - Male

KW - Rats

KW - Rats, Inbred Strains

KW - Sulfobromophthalein

KW - Tacrolimus

KW - Time Factors

UR - http://hdl.handle.net/10807/17730

M3 - Article

SN - 0041-1345

VL - 23

SP - 2802

EP - 2804

JO - Transplantation Proceedings

JF - Transplantation Proceedings

ER -

Effect of FK 506 chronic administration on bromosulphthalein hepatic excretion in rats

Abstract

Keywords

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