There are several reports dealing with the hepatic effect of FK 506,1–4 some of which are beneficial while others are adverse. Because the liver is a major target organ that is often the site of drug toxicity, studies directed at determining whether FK 506 affects specific hepatic function and/or its histologic appearance are important. Therefore, the present study was undertaken to examine bromosulphthalein (BSP) elimination kinetics in rats as a sensitive index of hepatic excretory function under the influence of FK 506 in the rat.
|Numero di pagine||3|
|Stato di pubblicazione||Pubblicato - 1991|
- Administration, Oral
- Dose-Response Relationship, Drug
- Rats, Inbred Strains
- Time Factors