Effect of FK 506 chronic administration on bromosulphthalein hepatic excretion in rats

Antonio Gasbarrini, H Farghali, M Sakr, R Venkataramanan, J Gavaler, Te Starzl, Dh Van Thiel

Risultato della ricerca: Contributo in rivistaArticolo in rivista

5 Citazioni (Scopus)

Abstract

There are several reports dealing with the hepatic effect of FK 506,1–4 some of which are beneficial while others are adverse. Because the liver is a major target organ that is often the site of drug toxicity, studies directed at determining whether FK 506 affects specific hepatic function and/or its histologic appearance are important. Therefore, the present study was undertaken to examine bromosulphthalein (BSP) elimination kinetics in rats as a sensitive index of hepatic excretory function under the influence of FK 506 in the rat.
Lingua originaleEnglish
pagine (da-a)2802-2804
Numero di pagine3
RivistaTransplantation Proceedings
Volume23
Stato di pubblicazionePubblicato - 1991

Keywords

  • Administration, Oral
  • Animals
  • Dose-Response Relationship, Drug
  • Kinetics
  • Liver
  • Male
  • Rats
  • Rats, Inbred Strains
  • Sulfobromophthalein
  • Tacrolimus
  • Time Factors

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