TY - JOUR
T1 - Effect of Early Expressed Human Milk on Insulin-Like Growth Factor 1 and Short-Term Outcomes in Preterm Infants.
AU - Serrao, Francesca
AU - Papacci, Patrizia
AU - Costa, Simonetta
AU - Giannantonio, Carmen
AU - Cota, Francesco
AU - Vento, Giovanni
AU - Romagnoli, Costantino
PY - 2016
Y1 - 2016
N2 - AIMS:\r\nPreterm breast milk contains high levels of bioactive components, including insulin-like growth factor 1 (IGF-1), that are reduced by Holder pasteurization. Animal studies have shown that milk-borne IGF-1 is likely absorbed intact in a bioactive form by the intestines. The aim of this study was to assess if early non-pasteurized expressed breast milk nutrition may affect IGF-1 plasma levels in premature infants. We also investigated the possible association between early expressed milk nutrition and short-term outcomes.\r\nMETHODS:\r\nFifty-two preterm infants with gestational age < 31 weeks were divided into two groups according to expressed breast milk intake (< or ≥ 50 mL/Kg/day) until 32 weeks of postmenstrual age when blood sampling for IGF-1 analysis was performed.\r\nRESULTS:\r\nIn our population, early expressed breast milk does not affect IGF-1 plasma levels (p 0.48). An association was observed between early expressed milk nutrition and a lower incidence of bronchopulmonary dysplasia, sepsis, feeding intolerance, need for parenteral nutrition and length of hospitalization.\r\nCONCLUSIONS:\r\nContrary to the results in some animal studies, our results did not seem to show that early expressed breast milk can help to maintain postnatal IGF-1 near foetal levels in preterm infants. The observed protective effect of expressed breast milk on short-term outcomes can be the starting point for further study of the effects of non-pasteurized human milk in preterm infants.
AB - AIMS:\r\nPreterm breast milk contains high levels of bioactive components, including insulin-like growth factor 1 (IGF-1), that are reduced by Holder pasteurization. Animal studies have shown that milk-borne IGF-1 is likely absorbed intact in a bioactive form by the intestines. The aim of this study was to assess if early non-pasteurized expressed breast milk nutrition may affect IGF-1 plasma levels in premature infants. We also investigated the possible association between early expressed milk nutrition and short-term outcomes.\r\nMETHODS:\r\nFifty-two preterm infants with gestational age < 31 weeks were divided into two groups according to expressed breast milk intake (< or ≥ 50 mL/Kg/day) until 32 weeks of postmenstrual age when blood sampling for IGF-1 analysis was performed.\r\nRESULTS:\r\nIn our population, early expressed breast milk does not affect IGF-1 plasma levels (p 0.48). An association was observed between early expressed milk nutrition and a lower incidence of bronchopulmonary dysplasia, sepsis, feeding intolerance, need for parenteral nutrition and length of hospitalization.\r\nCONCLUSIONS:\r\nContrary to the results in some animal studies, our results did not seem to show that early expressed breast milk can help to maintain postnatal IGF-1 near foetal levels in preterm infants. The observed protective effect of expressed breast milk on short-term outcomes can be the starting point for further study of the effects of non-pasteurized human milk in preterm infants.
KW - Human Milk
KW - Human Milk
UR - https://publicatt.unicatt.it/handle/10807/94501
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85006007553&origin=inward
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85006007553&origin=inward
U2 - 10.1371/journal.pone.0168139
DO - 10.1371/journal.pone.0168139
M3 - Article
SN - 1932-6203
SP - N/A-N/A
JO - PLoS One
JF - PLoS One
IS - Dec 14;11(12)
ER -