Effect of Early Expressed Human Milk on Insulin-Like Growth Factor 1 and Short-Term Outcomes in Preterm Infants.

Francesca Serrao*, Patrizia Papacci, Simonetta Costa, Carmen Giannantonio, Francesco Cota, Giovanni Vento, Costantino Romagnoli

*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivistaArticolo

7 Citazioni (Scopus)

Abstract

AIMS:\r\nPreterm breast milk contains high levels of bioactive components, including insulin-like growth factor 1 (IGF-1), that are reduced by Holder pasteurization. Animal studies have shown that milk-borne IGF-1 is likely absorbed intact in a bioactive form by the intestines. The aim of this study was to assess if early non-pasteurized expressed breast milk nutrition may affect IGF-1 plasma levels in premature infants. We also investigated the possible association between early expressed milk nutrition and short-term outcomes.\r\nMETHODS:\r\nFifty-two preterm infants with gestational age < 31 weeks were divided into two groups according to expressed breast milk intake (< or ≥ 50 mL/Kg/day) until 32 weeks of postmenstrual age when blood sampling for IGF-1 analysis was performed.\r\nRESULTS:\r\nIn our population, early expressed breast milk does not affect IGF-1 plasma levels (p 0.48). An association was observed between early expressed milk nutrition and a lower incidence of bronchopulmonary dysplasia, sepsis, feeding intolerance, need for parenteral nutrition and length of hospitalization.\r\nCONCLUSIONS:\r\nContrary to the results in some animal studies, our results did not seem to show that early expressed breast milk can help to maintain postnatal IGF-1 near foetal levels in preterm infants. The observed protective effect of expressed breast milk on short-term outcomes can be the starting point for further study of the effects of non-pasteurized human milk in preterm infants.
Lingua originaleInglese
pagine (da-a)N/A-N/A
RivistaPLoS One
Numero di pubblicazioneDec 14;11(12)
DOI
Stato di pubblicazionePubblicato - 2016

All Science Journal Classification (ASJC) codes

  • Biochimica, Genetica, Biologia Molecolare Generali
  • Scienze Agrarie e Biologiche Generali
  • Multidisciplinare

Keywords

  • Human Milk

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