Effect of blood glucose level on standardized uptake value (SUV) in 18F- FDG PET-scan: a systematic review and meta-analysis of 20,807 individual SUV measurements

Mahsa Eskian, Abass Alavi, Mirhojjat Khorasanizadeh, Benjamin L. Viglianti, Hans Jacobsson, Tara D. Barwick, Alipasha Meysamie, Sun K. Yi, Shingo Iwano, Bohdan Bybel, Federico Caobelli, Filippo Lococo, Joaquim Gea, Antonio Sancho-Muñoz, Jukka Schildt, Ebru Tatcı, Constantin Lapa, Georgia Keramida, Michael Peters, Raef R. BoktorJoemon John, Alexander G. Pitman, Tomasz Mazurek, Nima Rezaei

Risultato della ricerca: Contributo in rivistaArticolo in rivista

22 Citazioni (Scopus)


Objectives: To evaluate the effect of pre-scan blood glucose levels (BGL) on standardized uptake value (SUV) in 18F-FDG-PET scan. Methods: A literature review was performed in the MEDLINE, Embase, and Cochrane library databases. Multivariate regression analysis was performed on individual datum to investigate the correlation of BGL with SUVmax and SUVmean adjusting for sex, age, body mass index (BMI), diabetes mellitus diagnosis, 18F-FDG injected dose, and time interval. The ANOVA test was done to evaluate differences in SUVmax or SUVmean among five different BGL groups (< 110, 110–125, 125–150, 150–200, and > 200 mg/dl). Results: Individual data for a total of 20,807 SUVmax and SUVmean measurements from 29 studies with 8380 patients was included in the analysis. Increased BGL is significantly correlated with decreased SUVmax and SUVmean in brain (p < 0.001, p < 0.001,) and muscle (p < 0.001, p < 0.001) and increased SUVmax and SUVmean in liver (p = 0.001, p = 0004) and blood pool (p = 0.008, p < 0.001). No significant correlation was found between BGL and SUVmax or SUVmean in tumors. In the ANOVA test, all hyperglycemic groups had significantly lower SUVs compared with the euglycemic group in brain and muscle, and significantly higher SUVs in liver and blood pool. However, in tumors only the hyperglycemic group with BGL of > 200 mg/dl had significantly lower SUVmax. Conclusion: If BGL is lower than 200 mg/dl no interventions are needed for lowering BGL, unless the liver is the organ of interest. Future studies are needed to evaluate sensitivity and specificity of FDG-PET scan in diagnosis of malignant lesions in hyperglycemia.
Lingua originaleEnglish
pagine (da-a)224-237
Numero di pagine14
RivistaEuropean Journal of Nuclear Medicine and Molecular Imaging
Stato di pubblicazionePubblicato - 2019


  • 18F-FDG
  • Blood glucose level
  • Diabetes mellitus
  • PET quantification
  • PET scan
  • SUV


Entra nei temi di ricerca di 'Effect of blood glucose level on standardized uptake value (SUV) in 18F- FDG PET-scan: a systematic review and meta-analysis of 20,807 individual SUV measurements'. Insieme formano una fingerprint unica.

Cita questo