Abstract
The effect of acetyl-l-carnitine (ALC) on behavioral deficits following neonatal anoxia (N2 100% for 25 min at 30 h after birth) was
studied in the rat. Transient hyperactivity at P20–P45 postnatal days and permanent spatial memory deficits were shown by anoxic rats.
A chronic ALC treatment (50 mg/kg per die injected intraperitoneally from P2, after anoxia, to P60) significantly reduced the transient
increase in sniffing, rearing and locomotory activity of anoxic rats, but, mostly, ameliorated the spatial memory performances in a maze
at P30–P40 and in a water maze at P50–P60. No behavioral changes were seen in ALC-treated animals that received sham-exposure at
birth. On the basis of these results, the use of ALC for the treatment of perinatal asphyctic insults in children is suggested
Lingua originale | English |
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pagine (da-a) | 201-205 |
Numero di pagine | 5 |
Rivista | Neuroscience Letters |
Volume | 1997 |
Stato di pubblicazione | Pubblicato - 1997 |
Keywords
- Acetyl-l-carnitine
- Attention deficit-hyperactivity disorder
- Hyperactivity
- Neuroprotection
- Perinatal asphyxia
- Spatial memory