Effect of α-lipoic acid on platelet reactivity in type 1 diabetic patients

Dario Pitocco, Gaetano Antonio Lanza, Filippo Crea, Roberto Mollo, Francesco Zaccardi, Giancarla Scalone, Andrea Macchione, Giuseppe Scavone, Paola Rizzo, Eliano Pio Navarese, Giovanni Ghirlanda, Andrea Manto

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

11 Citazioni (Scopus)

Abstract

OBJECTIVE: Type 1 diabetes is associated with increased platelet reactivity. We investigated whether α-lipoic acid (ALA) has any effect on platelet reactivity in these patients. RESEARCH DESIGN AND METHODS: We randomly assigned 51 type 1 diabetic patients to ALA (600 mg once daily) or placebo for 5 weeks. Platelet reactivity was evaluated by the PFA-100 method and by measuring CD41 and CD62 platelet expression. C-reactive protein (CRP) and 8-iso-prostaglandin F2α serum levels also were measured. RESULTS: Baseline variables were similar in the two groups. After treatment, closure time was longer (P = 0.006) and CD62P platelet expression was lower, both before (P = 0.002) and after (P = 0.009) ADP stimulation in the ALA group compared with the placebo group. CRP and 8-iso-prostaglandin F2α levels showed no differences between the two groups. CONCLUSIONS: Our data show that ALA reduces measures of platelet reactivity ex vivo in type 1 diabetic patients, independently of antioxidant or anti-inflammatory effects.
Lingua originaleEnglish
pagine (da-a)196-197
Numero di pagine2
RivistaDiabetes Care
Volume36
DOI
Stato di pubblicazionePubblicato - 2012

Keywords

  • C reactive protein

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