Ecstasy (MDMA)-addicted subjects show increased serum levels of brain-derived neurotrophic factor, independently from a rise of drug-induced psychotic symptoms

Valerio Ricci, Giovanni Martinotti, Gianfranco Spalletta, Pietro Bria, F Angelucci, I Palladino, C Caltagirone

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

The recreational drug 'ecstasy'[3,4-methylenedioxymethamphetamine (MDMA)] exerts a potent action on central serotonergic and dopaminergic neurons. These neurons utilize neurotrophins for their survival and function. In order to explore MDMA effects on neurotrophins, we measured by enzyme-linked immunosorbent assay the serum levels of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in 'ecstasy-addicted', 'ecstasy-addicted with signs of psychosis' and 'healthy' subjects. We found that BDNF serum levels were significantly increased in both groups of 'ecstasy-addicted' as compared with 'healthy subjects', supporting the hypothesis that BDNF is involved in MDMA action.
Lingua originaleEnglish
pagine (da-a)365-367
Numero di pagine3
RivistaAddiction Biology
Volume15
DOI
Stato di pubblicazionePubblicato - 2010

Keywords

  • Adolescent
  • Brain
  • Brain-Derived Neurotrophic Factor
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Male
  • N-Methyl-3,4-methylenedioxyamphetamine
  • Nerve Growth Factor
  • Psychoses, Substance-Induced
  • Substance-Related Disorders
  • Young Adult

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